Epigenetic clocks suggest accelerated aging in patients with isolated REM Sleep Behavior Disorder

被引：3

作者：

Baldelli, Luca ^{[1
,2
]}

Pirazzini, Chiara ^{[3
]}

Sambati, Luisa ^{[2
]}

Ravaioli, Francesco ^{[3
]}

Gentilini, Davide ^{[4
,5
]}

Calandra-Buonaura, Giovanna ^{[1
,2
]}

Guaraldi, Pietro ^{[2
]}

Franceschi, Claudio ^{[3
,6
]}

Cortelli, Pietro ^{[1
,2
]}

Garagnani, Paolo ^{[3
]}

Bacalini, Maria Giulia ^{[2
]}

Provini, Federica ^{[1
,2
]}

机构：

[1] Univ Bologna, Dept Biomed & NeuroMotor Sci DiBiNeM, Bologna, Italy

[2] IRCCS Ist Sci Neurolog Bologna, Bologna, Italy

[3] Univ Bologna, Dept Med & Surg Sci DIMEC, Bologna, Italy

[4] Univ Pavia, Dept Brain & Behav Sci, Pavia, Italy

[5] Ist Auxol Italiano IRCCS, Bioinformat & Stat Genom Unit, Milan, Italy

[6] Lobachevsky State Univ, Inst Informat Technol Math & Mech, Nizhnii Novgorod, Russia

来源：

NPJ PARKINSONS DISEASE | 2023年 / 9卷 / 01期

关键词：

AGE;

D O I：

10.1038/s41531-023-00492-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Isolated REM Sleep Behavior Disorder (iRBD) is the strongest prodromal marker for alpha-synucleinopathies. Overt alpha-synucleinopathies and aging share several mechanisms, but this relationship has been poorly investigated in prodromal phases. Using DNA methylation-based epigenetic clocks, we measured biological aging in videopolysomnography confirmed iRBD patients, videopolysomnography-negative and population-based controls. We found that iRBDs tended to be epigenetically older than controls, suggesting that accelerated aging characterizes prodromal neurodegeneration.

引用

页数：4

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