Light-triggered cardiac microphysiological model

被引：3

作者：

Vurro, V. ^{[1
]}

Shani, K. ^{[2
]}

Ardona, H. A. M. ^{[2
]}

Zimmerman, J. F. ^{[2
]}

Sesti, V. ^{[1
,2
,3
]}

Lee, K. Y. ^{[2
,3
,4
,5
]}

Jin, Q. ^{[2
]}

Bertarelli, C. ^{[1
,2
,3
]}

Parker, K. K. ^{[2
]}

Lanzani, G. ^{[1
,6
]}

机构：

[1] Ist Italiano Teconol, Ctr Nanosci & Technol, I-20133 Milan, Italy

[2] Harvard Univ, John A Paulson Sch Engn & Appl Sci, Dis Biophys Grp, Boston, MA 02134 USA

[3] Univ Calif Irvine, Samueli Sch Engn, Dept Chem & Biomol Engn, Irvine, CA 92697 USA

[4] Politecn Milan, Dept Chem Mat & Chem Engn Giulio Natta, I-20133 Milan, Italy

[5] Sejong Univ, Dept Integrat Biosci & Biotechnol, Seoul, South Korea

[6] Politecn Milan, Dept Phys, I-20133 Milan, Italy

来源：

APL BIOENGINEERING | 2023年 / 7卷 / 02期

关键词：

OPTOGENETIC CONTROL; THIN-FILMS; MUSCLE; TISSUE; STIMULATION; MODULATION; ROBOTICS; NERVE;

D O I：

10.1063/5.0143409

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Light is recognized as an accurate and noninvasive tool for stimulating excitable cells. Here, we report on a non-genetic approach based on organic molecular phototransducers that allows wiring- and electrode-free tissue modulation. As a proof of concept, we show photostimulation of an in vitro cardiac microphysiological model mediated by an amphiphilic azobenzene compound that preferentially dwells in the cell membrane. Exploiting this optical based stimulation technology could be a disruptive approach for highly resolved cardiac tissue stimulation.

引用

页数：9

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