Larotrectinib treatment for infantile fibrosarcoma in newborns: a case report and literature review

被引:0
|
作者
Wang, Dandan [1 ,2 ]
Zhang, Fanhui [1 ,2 ]
Feng, Wanli [1 ,2 ]
Pan, Jiarong [1 ,2 ]
Yuan, Tianming [1 ,2 ]
机构
[1] Zhejiang Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth, Dept Neonatol,Sch Med, Hangzhou, Peoples R China
[2] Lab Diag & Therapy Neonatal Dis Zhejiang Prov, Hangzhou, Peoples R China
来源
FRONTIERS IN ONCOLOGY | 2023年 / 13卷
关键词
infantile fibrosarcoma; newborn; ETV6-NTRK3; larotrectinib; treatment; SECRETORY CARCINOMA; REARRANGEMENT;
D O I
10.3389/fonc.2023.1206833
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Infantile fibrosarcoma (IFS) is a rare tumor in childhood characterized by a single, localized, painless mass that grows rapidly but has a relatively indolent biological behavior and a favorable prognosis. Eighty-five percent of infantile fibrosarcomas are associated with t (12;15) (p13;25) chromosomal translocation resulting in ETV6-NTRK3 gene fusion, which provides the target for targeted therapy. Here, we report a case of IFS in a newborn with a mass in the left lower extremity confirmed by imaging, histopathological examination, tissue FISH testing, and high-throughput sequencing to detect gene rearrangement. Based on gene fusion targeted drug testing results, the patient was treated with standard doses of larotrectinib, resulting in significant mass shrinkage with no adverse effects, demonstrating the treatment effect of targeted therapy. This case provides a reference for using larotrectinib in newborns with IFS.
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页数:5
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