PEN-coated superparamagnetic iron-mediated delivery of siSnail2 to inhibit metastasis and promote ferroptosis in the treatment of cancer

被引：3

作者：

Hu, Yue ^{[1
,2
]}

Nie, Qing ^{[3
]}

Cong, Xianling ^{[2
]}

Wu, Wen ^{[1
]}

Wu, Qiong ^{[1
]}

Liu, Qihui ^{[1
]}

Li, Yuanyuan ^{[1
]}

Liu, Haiyan ^{[4
]}

Ge, Jingyan ^{[5
]}

Chen, Fangfang ^{[1
,6
]}

机构：

[1] Jilin Univ, China Japan Union Hosp, Nanomed & Translat Res Ctr, Key Lab Pathobiol,Minist Educ, Changchun 130033, Peoples R China

[2] Jilin Univ, Dept Tissues Bank, China Japan Union Hosp, Changchun 130033, Peoples R China

[3] Shandong First Med Univ & Amp, Shandong Prov Qianfoshan Hosp, Dept Gen Surg, Affiliated Hosp 1, Jinan 250014, Peoples R China

[4] Jilin Univ, Coll Basic Med Sci, Dept Anat, Changchun 130021, Peoples R China

[5] Jilin Univ, Coll Basic Med Sci, Dept Physiol, Changchun 130021, Peoples R China

[6] Jilin Univ, Nanomed & Translat Res Ctr, Key Lab Pathobiol, Minist Educ,Bethune Hosp 3, 126 Xiantai St, Changchun 130033, Jilin, Peoples R China

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2024年 / 650卷

基金：

中国国家自然科学基金;

关键词：

CLIO-NH; 2; Snail2; Metastasis; Ferroptosis; Cancer; EMT; CARCINOMA; SIRNA;

D O I：

10.1016/j.ijpharm.2023.123728

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Cancer represents a significant global public health challenge, and conventional cancer therapies such as surgery and chemoradiotherapy are not enough due to the increased complexity of cancer. Nanotechnology has the potential to revolutionize tumor treatments by integrating gene therapy, tumor targeting, and drug delivery. In this study, we demonstrated that Snail2 plays a crucial role in the migration and invasion of lung and liver carcinoma. We proposed a novel approach to synergize the aminated crosslinking dextran coat of super-paramagnetic iron oxide nano worms (CLIO-NH2, CN) with small interfering Snail2 RNA (siSnail2). The effi-ciency of siSnail2 delivery was significantly improved by coating CN with N-Isopropylacrylamide-modified polyethylenimine (CNP). In vitro, experiments revealed that CNP@siSnail2 effectively inhibited cancer cell EMT, migration, and invasion. Moreover, CNP@ siSnail2 promoted cancer cell death through various mechanisms, including apoptosis and ferroptosis. The combination of CNP@ siSnail2 and cisplatin significantly improved the anti-tumor effect of the treatment. Animal models demonstrated that the combined treatment of CNP@ siSnail2 and cisplatin resulted in excellent tumor inhibition effects. Our findings provide a potential combined treatment strategy for cancer therapy.

引用

页数：10