Gonadotropin-Dependent Precocious Puberty: Single-Center Experience From Western India

ObjectiveTo describe the characteristics of gonadotropin-dependent precocious puberty (GDPP) in Indian children.MethodsClinical profiles of GDPP (n=78, 61 females) and premature thelarche (n=12) from a single center in Western India were retrospectively studied.ResultsPubertal onset was earlier in boys than girls (29 vs 75 months, respectively; P=0.008). The basal luteinizing hormone (LH) was & GE;0.3 mIU/mL, except 18% of GDPP girls. At 60 minutes after GnRHa-stimulation, all patients (except one girl) had LH & GE;5 mIU/mL. The GnRHa-stimulated LH/FSH ratio was & GE;0.34 at 60 minutes in girls with GDPP unlike premature thelarche. Only one girl had an allergic reaction to long-acting GnRH agonist. Among GnRH agonist-treated girls (n=24), the predicted final adult height was -1.67 & PLUSMN;1.5 SDS, whereas the attained final height was -0.25 & PLUSMN;1.48 SDS.ConclusionWe establish the safety and efficacy of long acting GnRH agonist therapy in Indian children with GDPP. The 60-minute stimulated serum LH/FSH of & GE;0.34 differentiated GDPP from premature thelarche.