The Role of Intracellular Signaling Molecules in Macrophage Activation by Peat Humic Acids

被引：0

作者：

Trofimova, E. S. ^{[1
,2
]}

Zykova, M. V. ^{[2
]}

Ligacheva, A. A. ^{[1
]}

Danilets, M. G. ^{[1
]}

Sherstoboev, E. Yu. ^{[1
]}

Selivanova, N. S. ^{[1
]}

Belousov, M. V. ^{[2
]}

Logvinova, L. A. ^{[2
]}

Zhdanov, V. V. ^{[1
]}

机构：

[1] Russian Acad Sci, ED Goldberg Res Inst Pharmacol & Regenerat Med, Tomsk Natl Res Med Ctr, Tomsk, Russia

[2] Siberian State Med Univ, Minist Hlth Russian Federat, Tomsk, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2023年 / 175卷 / 03期

关键词：

humic acids; macrophages; nitric oxide; signaling molecules; TLR2;

D O I：

10.1007/s10517-023-05866-3

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Humic acids isolated by sodium pyrophosphate extraction from various types of peat activate macrophages in the classical proinflammatory pathway and stimulate nitric oxide production by these cells. This effect is mediated by activation of intracellular signaling pathways involving MAPK p38, PI3K, MEK 1/2 kinase, cAMP, and NF-& kappa;B via TLR-2 and TLR-4 receptors.

引用

页码：353 / 357

页数：5

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