Hepatic Stellate Cells: Dictating Outcome in Nonalcoholic Fatty Liver Disease

被引：23

作者：

Wiering, Leke ^{[1
,2
,3
,4
]}

Subramanian, Pallavi ^{[5
,6
,7
]}

Hammerich, Linda ^{[8
]}

机构：

[1] Charite Univ Med Berlin, Berlin, Germany

[2] Free Univ Berlin, Berlin, Germany

[3] Humboldt Univ, Dept Hepatol & Gastroenterol, Campus Virchow Klinikum, Berlin, Germany

[4] Campus Charite Mitte, Berlin, Germany

[5] Charite Univ Med Berlin, BIH Biomed Innovat Acad, BIH Charite Jr Clinician Scientist Program, Berlin Inst Hlth, Berlin, Germany

[6] Univ Hosp, Inst Clin Chem & Lab Med, Dresden, Germany

[7] Tech Univ Dresden, Fac Med, Dresden, Germany

[8] Charite Univ Med Berlin, Dept Hepatol & Gastroenterol, Campus Virchow Klinikum, Augustenburger Pl 1, D-13353 Berlin, Germany

来源：

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY | 2023年 / 15卷 / 06期

关键词：

Hepatic Stellate Cell; NAFLD; Fibrosis; NASH; GROWTH-FACTOR RECEPTOR; REGULATORY T-CELLS; FACTOR-BETA; SPHINGOSINE; 1-PHOSPHATE; FREE-CHOLESTEROL; INFLAMMATORY CYTOKINES; FIBROSIS RESOLUTION; PROMOTE FIBROSIS; GENE-EXPRESSION; SONIC HEDGEHOG;

D O I：

10.1016/j.jcmgh.2023.02.010

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Nonalcoholic fatty liver disease (NAFLD) is a fast growing, chronic liver disease affecting w25% of the global population. Nonalcoholic fatty liver disease severity ranges from the less severe simple hepatic steatosis to the more advanced nonalcoholic steatohepatitis (NASH). The presence of NASH predisposes individuals to liver fibrosis, which can further progress to cirrhosis and hepatocellular carcinoma. This makes hepatic fibrosis an important indicator of clinical outcomes in patients with NASH. Hepatic stellate cell activation dictates fibrosis development during NASH. Here, we discuss recent advances in the analysis of the profibrogenic pathways and mediators of hepatic stellate cell activation and inactivation, which ultimately determine the course of disease in nonalcoholic fatty liver disease/

引用

页码：1277 / 1292

页数：16

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