Resurgence of congenital syphilis: new strategies against an old foe

被引：25

作者：

Moseley, Philip ^{[1
]}

Bamford, Alasdair ^{[2
,3
]}

Eisen, Sarah ^{[4
]}

Lyall, Hermione ^{[5
]}

Kingston, Margaret ^{[6
]}

Thorne, Claire ^{[3
]}

Pinera, Cecilia ^{[7
]}

Rabie, Helena ^{[8
,9
]}

Prendergast, Andrew J. ^{[10
,11
]}

Kadambari, Seilesh ^{[2
,3
,12
]}

机构：

[1] Univ Queensland, Univ Queensland Frazer Inst, Brisbane, Qld, Australia

[2] Great Ormond St Hosp Children NHS Fdn Trust, Dept Paediat Infect Dis, London, England

[3] UCL, Great Ormond St Inst Child Hlth, London, England

[4] Univ Coll London Hosp NHS Fdn Trust, London, England

[5] Imperial Coll Healthcare NHS Trust, London, England

[6] Manchester Univ NHS Fdn Trust, Manchester, England

[7] Univ Chile, Med Fac, Santiago, Chile

[8] Stellenbosch Univ, Dept Paediat & Child Hlth, Stellenbosch, South Africa

[9] Tygerberg Acad Hosp, Cape Town, South Africa

[10] Zvitambo Inst Maternal & Child Hlth Res, Harare, Zimbabwe

[11] Queen Mary Univ London, Blizard Inst, London, England

[12] Great Ormond St Hosp Children NHS Fdn Trust, Dept Paediat Infect Dis, London WC1N 3JH, England

来源：

LANCET INFECTIOUS DISEASES | 2024年 / 24卷 / 01期

关键词：

PREGNANT-WOMEN; SECONDARY SYPHILIS; ORAL AMOXICILLIN; HIV TESTS; AZITHROMYCIN; PREVENTION; DIAGNOSIS; METAANALYSIS; CEFTRIAXONE; STILLBIRTHS;

D O I：

10.1016/S1473-3099(23)00314-6

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Congenital syphilis is a major global cause of fetal loss, stillbirth, neonatal death, and congenital infection. In 2020, the global rate of congenital syphilis was 425 cases per 100 000 livebirths-substantially higher than WHO's elimination target of 50 cases per 100 000 livebirths. Case rates are rising in many high-income countries, but remain low compared with those in low-income and middle-income settings. This Review aims to summarise the current epidemiology and knowledge on transmission and treatment of syphilis in pregnancy, and proposes measures to reduce the rising incidence seen worldwide. We also describe emerging diagnostic and treatment tools to prevent vertical transmission and improve management of congenital syphilis. Finally, we outline a programme of public health priorities, which include research, clinical, and preventive strategies.

引用

页码：e24 / e35

页数：12

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