Novel DABCO based acidic ionic liquid as a green protocol for the synthesis of thiazolidin-4-one derivatives and cytotoxic activity evaluation on human breast cancer cell line

A novel [C4H10-DABCO][ClO4](2) DABCO based protic acid supported ionic liquid has been synthesized, characterized, and evaluated as an efficient, economic, and reusable catalyst for the one pot, three component synthesis of 1,3-thiazolidin-4-one in an aqueous medium with high to excellent yield. This study compares DABCO based ionic liquids [H-2-DABCO][HSO4](2), [H-2-DABCO][H2PO4](2), [H-2-DABCO][ClO4](2), and [C4H10-DABCO][ClO4](2) to highlight the impact of cations and anions on the catalytic applicability and moisture-resistance properties. The DABCO based Bifunctional Acidic Ionic Liquid (DBAIL) catalyst was effectively recycled five times without losing significant catalytic activity. Five of the synthesized derivatives were evaluated for their cytotoxic activity against the MCF-7 cell line using MTT assay, and the compounds showed moderate to good activity.