Living Donor Kidney Transplant in Recipients With Glomerulonephritis: Donor Recipient Biologic Relationship and Allograft Outcomes

被引:1
|
作者
El-Rifai, Rasha [1 ]
Bregman, Adam [1 ]
Klomjit, Nattawat [1 ]
Spong, Richard [1 ]
Jackson, Scott [2 ]
Nachman, Patrick H. [1 ]
Riad, Samy [1 ,3 ]
机构
[1] Univ Minnesota, Dept Med, Div Renal Dis & Hypertens, Minneapolis, MN 55455 USA
[2] MHlth Fairview, Complex Care Analyt, Minneapolis, MN USA
[3] Mayo Clin, Div Nephrol & Hypertens, Rochester, MN 55905 USA
关键词
graft survival; long term outcomes; disease recurrence; living related donor; glomerulonephritis; FOCAL SEGMENTAL GLOMERULOSCLEROSIS; LUPUS NEPHRITIS; RISK; NEPHROPATHY; SURVIVAL; GENE;
D O I
10.3389/ti.2023.11068
中图分类号
R61 [外科手术学];
学科分类号
摘要
Using the Scientific Registry of Transplant Recipients, we examined the association between donor-recipient biologic relationship and long-term recipient and allograft survival among glomerulonephritis (GN) patients. Four GN types were studied: membranous nephropathy, IgA, lupus-associated nephritis, and focal segmental glomerulosclerosis (FSGS). We identified all adult primary living-donor recipients between 2000 and 2018 (n = 19,668): related (n = 10,437); unrelated (n = 9,231). Kaplan-Meier curves were generated for the recipient, death-censored graft survival and death with functioning graft through ten years post-transplant. Multivariable Cox proportional hazard models were used to examine the association between the donor-recipient relationship and outcomes of interest. There was an increased risk for acute rejection by 12 months post-transplant among the unrelated compared to the related group in IgA (10.1% vs. 6.5%, p<0.001), FSGS (12.1% vs. 10%, p-0.016), and lupus nephritis (11.8% vs. 9.2%; p-0.049). The biological donor-recipient relationship was not associated with a worse recipient or graft survival or death with functioning graft in the multivariable models. These findings are consistent with the known benefits of living-related-donor kidney transplants and counter the reports of the potential adverse impact of the donor-recipient biologic relationship on allograft outcomes.
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页数:10
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