Synthesis of rifaximin-loaded ZnO@ZIF-8 nanocomposites for Staphylococcal biofilm eradication and related infection therapy

被引：1

作者：

Liu, Tianci ^{[1
]}

Zhang, Aoxue ^{[2
,3
]}

Zhou, Minyuan ^{[4
]}

Wang, Yuhang ^{[1
]}

Xie, Shuyu ^{[2
,3
]}

Lu, Zhe-Xue ^{[1
]}

机构：

[1] Huazhong Agr Univ, Coll Sci, Wuhan 430070, Peoples R China

[2] Huazhong Agr Univ, Natl Reference Lab Vet Drug Residues HZAU, Wuhan 430070, Peoples R China

[3] Huazhong Agr Univ, MAO Key Lab Detect Vet Drug Residues, Wuhan 430070, Peoples R China

[4] Huazhong Agr Univ, Coll Life Sci & Technol, Wuhan 430070, Peoples R China

来源：

NEW JOURNAL OF CHEMISTRY | 2023年 / 47卷 / 08期

关键词：

KILLING EFFICIENCY; BACTERIAL-GROWTH; NANOPARTICLES; PENETRATION; ZNO;

D O I：

10.1039/d2nj05548a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Bacterial biofilm related infectious diseases are a fatal threat to human health. The synthesis and application of novel nanocomposites with effective anti-biofilm activity has attracted great attention. Herein, using small-size ZnO nanoparticles as half-sacrificial templates, a general method for the synthesis of drug-loaded ZnO@ZIF-8 nanocomposites with pH-responsive targeting, self-antibacterial activity and high drug loading has been developed. Rifaximin was then loaded to form rifaximin-loaded ZnO@ZIF-8 (R-ZnO-ZIF) nanocomposites for Staphylococcal biofilm eradication and related infection therapy. The average size and the zeta potential of R-ZnO-ZIF are 60 nm and +25.7 mV, respectively. Anti-biofilm experiments demonstrated that the anti-biofilm activity of R-ZnO-ZIF was much better than that of rifaximin and rifaximin-loaded ZIF-8 nanocomposites. Furthermore, a mouse wound infection model was used to evaluate the therapeutic effect of R-ZnO-ZIF for bacterial infection. The results showed that R-ZnO-ZIF is a promising material for bacterial biofilm related infection therapy.

引用

页码：3825 / 3833

页数：9