Butyrate Protects against SARS-CoV-2-Induced Tissue Damage in Golden Hamsters

被引：2
|
作者：
Yu, Huan [1 ]
Yuan, Lunzhi [2 ]
Yan, Zhigang [1 ]
Zhou, Ming [2 ]
Ye, Jianghui [2 ]
Wu, Kun [2 ]
Chen, Wenjia [1 ]
Chen, Rirong [1 ]
Xia, Ningshao [2 ]
Guan, Yi [1 ,3 ,4 ]
Zhu, Huachen [1 ,3 ,4 ]
机构：
[1] Shantou Univ, Joint Inst Virol, Guangdong Hong Kong Joint Lab Emerging Infect Dis, Joint Lab Int Collaborat Virol & Emerging Infect D, Shantou 515063, Peoples R China
[2] Xiamen Univ, Natl Inst Diagnost & Vaccine Dev Infect Dis, State Key Lab Vaccines Infect Dis, NMPA Key Lab Res & Evaluat Infect Dis Diagnost Tec, Xiamen 361102, Peoples R China
[3] Univ Hong Kong, Li Ka Shing Fac Med, Sch Publ Hlth, State Key Lab Emerging Infect Dis SKLEID, Hong Kong, Peoples R China
[4] EKIH Gewuzhikang Adv Pathogen Res Inst, Shenzhen 518045, Peoples R China
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 18期
关键词：
butyrate; SARS-CoV-2; golden hamster; type I IFN; apoptosis; oxidative stress; DIETARY FIBER; ACE2;
D O I：
10.3390/ijms241814191
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Butyrate, produced by gut microbe during dietary fiber fermentation, has anti-inflammatory and antioxidant effects on chronic inflammation diseases, yet it remains to be explored whether butyrate has protective effects against viral infections. Here, we demonstrated that butyrate alleviated tissue injury in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected golden hamsters supplemented with butyrate before and during the infection. Butyrate-treated hamsters showed augmentation of type I interferon (IFN) response and activation of endothelial cells without exaggerated inflammation. In addition, butyrate regulated redox homeostasis by enhancing the activity of superoxide dismutase (SOD) to inhibit excessive apoptotic cell death. Therefore, butyrate exhibited effective prevention against SARS-CoV-2 by upregulating antiviral immune responses and promoting cell survival.
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页数：14
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