Diagnostic value of circulating microRNA-21 in chronic lung allograft dysfunction after bilateral cadaveric and living-donor lobar lung transplantation*

被引:1
|
作者
Shiotani, Toshio [1 ,2 ]
Sugimoto, Seiichiro [1 ,2 ,3 ]
Tomioka, Yasuaki [1 ,2 ]
Yamamoto, Haruchika [2 ]
Tanaka, Shin [1 ,2 ]
Miyoshi, Kentaroh [2 ]
Suzawa, Ken [2 ]
Shien, Kazuhiko [2 ]
Yamamoto, Hiromasa [2 ]
Okazaki, Mikio [2 ]
Toyooka, Shinichi [2 ]
机构
[1] Okayama Univ Hosp, Organ Transplant Ctr, Okayama, Japan
[2] Okayama Univ Hosp, Dept Gen Thorac Surg, Okayama, Japan
[3] Okayama Univ Hosp, Organ Transplant Ctr, 2-5-1 Shikata Cho, Kita Ku, Okayama 7008558, Japan
关键词
Biomarker; Chronic lung allograft dysfunction; Lung transplantation; Living -donor lobar lung transplantation; Micro; -RNA; BRONCHIOLITIS OBLITERANS SYNDROME; ACUTE CELLULAR REJECTION; INTERNATIONAL-SOCIETY; HEART; BIOMARKERS; SURVIVAL; PLASMA;
D O I
10.1016/j.heliyon.2023.e14903
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Background: MicroRNAs (miRNAs) involved in the pathogenesis of pulmonary fibrosis have been shown to be associated with the development of chronic lung allograft dysfunction (CLAD) after lung transplantation (LT). We investigated the role of circulating miRNAs in the diagnosis of CLAD after bilateral LT, including cadaveric LT (CLT) and living-donor lobar LT (LDLLT). Methods: The subjects of this retrospective study were 37 recipients of bilateral CLT (n = 23) and LDLLT (n = 14), and they were divided into a non-CLAD group (n = 24) and a CLAD group (n = 13). The plasma miRNA levels of the two groups were compared, and correlations between their miRNAs levels and percent baseline forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), and total lung capacity (TLC) values were calculated from one year before to one year after the diagnosis of CLAD. Results: The plasma levels of both miR-21 and miR-155 at the time of the diagnosis of CLAD were significantly higher in the CLAD group than in the non-CLAD group (miR-21, P = 0.0013; miR155, P = 0.042). The miR-21 levels were significantly correlated with the percent baseline FEV1, FVC, and TLC value of one year before and at the time of diagnosis of CLAD (P < 0.05). A receiver operating characteristic curve analysis of the performance of miR-21 levels in the diagnosis of CLAD yielded an area under the curve of 0.89. Conclusion: Circulating miR-21 appears to be of potential value in diagnosing CLAD after bilateral LT.
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页数:9
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