FooDrugs: a comprehensive food-drug interactions database with text documents and transcriptional data

被引：3

作者：

Lacruz-Pleguezuelos, Blanca ^{[1
]}

Piette, Oscar ^{[1
]}

Garranzo, Marco ^{[1
]}

Perez-Serrano, David ^{[1
]}

Milesevic, Jelena ^{[2
,3
]}

Espinosa-Salinas, Isabel ^{[4
]}

Ramirez de Molina, Ana ^{[4
]}

Laguna, Teresa ^{[1
]}

Carrillo de Santa Pau, Enrique ^{[1
]}

机构：

[1] CEI UAM CSIC, IMDEA Food Inst, Precis Nutr & Canc Res Program, Computat Biol Grp, Carretera Cantoblanco 8, Madrid 28049, Spain

[2] Univ Belgrade, Inst Med Res, Natl Inst Republ Serbia, Ctr Res Excellence Nutr & Metab, Tadeusa Koscuska 1,PAK 104201, Belgrade 11158, Serbia

[3] Capac Dev Nutr CAPNUTRA, Trnska 3, Belgrade 11000, Serbia

[4] CEI UAM CSIC, IMDEA Food Inst, GENYAL Platform Nutr & Hlth, Carretera Cantoblanco 8, Madrid 28049, Spain

来源：

DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION | 2023年 / 2023卷

关键词：

VITAMIN-D; RESVERATROL; DISCOVERY; RESOURCE; MODE;

D O I：

10.1093/database/baad075

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Food-drug interactions (FDIs) occur when a food item alters the pharmacokinetics or pharmacodynamics of a drug. FDIs can be clinically relevant, as they can hamper or enhance the therapeutic effects of a drug and impact both their efficacy and their safety. However, knowledge of FDIs in clinical practice is limited. This is partially due to the lack of resources focused on FDIs. Here, we describe FooDrugs, a database that centralizes FDI knowledge retrieved from two different approaches: a natural processing language pipeline that extracts potential FDIs from scientific documents and clinical trials and a molecular similarity approach based on the comparison of gene expression alterations caused by foods and drugs. FooDrugs database stores a total of 3 430 062 potential FDIs, with 1 108 429 retrieved from scientific documents and 2 321 633 inferred from molecular data. This resource aims to provide researchers and clinicians with a centralized repository for potential FDI information that is free and easy to use.Database URL: https://zenodo.org/records/8192515Database DOI: https://doi.org/10.5281/zenodo.6638469

引用

页数：13

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