Dendrobium huoshanense stem polysaccharide ameliorates alcohol-induced gastric ulcer in rats through Nrf2-mediated strengthening of gastric mucosal barrier

被引:32
|
作者
Ye, Hui-Yu
Shang, Zhen-Zi [1 ]
Zhang, Feng-Yun [2 ]
Zha, Xue-Qiang [1 ]
Li, Qiang-Ming [1 ]
Luo, Jian-Ping [1 ]
机构
[1] Hefei Univ Technol, Sch Food & Biol Engn, Hefei 230009, Peoples R China
[2] Anhui Med Univ, Sch Basic Med Sci, Hefei 230032, Peoples R China
基金
中国国家自然科学基金;
关键词
Dendrobium huoshanense polysaccharide; Gastric mucosal barrier; Nrf2; PROTON PUMP INHIBITORS; ETHANOL; INJURY; LESION; ACID;
D O I
10.1016/j.ijbiomac.2023.124001
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
This study aimed to explore whether Dendrobium huoshanense stem polysaccharide (cDHPS) ameliorates alcohol -induced gastric ulcer (GU) through the strengthening effect of the gastric mucosal barrier in rats and its potential mechanism. In normal rats, the pretreatment of cDHPS effectively strengthened gastric mucosal barrier by increasing mucus secretion and tight junction protein expression. In GU rats, cDHPS supplementation effectively alleviated alcohol-induced gastric mucosal injury and nuclear factor kappa B (NF-kappa B)-driven inflammation by strengthening gastric mucosal barrier. Moreover, cDHPS significantly activated nuclear factor E2-related factor 2 (Nrf2) signaling and promoted antioxidant enzymes activities in both normal and GU rats. These results sug-gested that the pretreatment of cDHPS could strengthen gastric mucosal barrier to inhibit oxidative stress and NF-kappa B-driven inflammation induced gastric mucosal injury, which was likely related to the activation of Nrf2 signaling.
引用
收藏
页数:11
相关论文
共 14 条
  • [1] Antioxidant ameliorates action of cytoprotection on alcohol-induced gastric mucosal damage in rats
    Oh, TY
    Ahn, BO
    Kim, WB
    Lee, JS
    Hahm, KB
    FREE RADICAL BIOLOGY AND MEDICINE, 2002, 33 : S336 - S336
  • [2] Multi-omics analysis reveals the pre-protective mechanism of Dendrobium flexicaule polysaccharide against alcohol-induced gastric mucosal injury
    Wang, Fei
    Yuan, Chong
    Deng, Rui
    Liu, Yifei
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2025, 291
  • [3] Xiangshao Decoction alleviates gastric mucosal injury through NRF2 signaling pathway and reduces neuroinflammation in gastric ulcer rats
    Gong, Haiying
    Han, Di
    Luo, Zichen
    Zhu, Qingping
    Zhu, Xiaolin
    Liu, Sen
    Chen, Diping
    PHYTOMEDICINE, 2023, 118
  • [4] Dendrobium huoshanense stem polysaccharide ameliorates high fructose-induced hepatocyte lipid accumulation through decreasing miR-429 to upregulate RIP2
    Li, Feng
    Zhu, Lei-Lei
    Gao, Lei-Lei
    Pan, Ying
    Han, Bang-Xing
    Kong, Ling-Dong
    JOURNAL OF FUNCTIONAL FOODS, 2023, 107
  • [5] Olmesartan niosomes ameliorates the Indomethacin-induced gastric ulcer in rats: Insights on MAPK and Nrf2/HO-1 signaling pathway
    Sallam, Al-Aliaa M.
    Darwish, Samar F.
    El-Dakroury, Walaa A.
    Radwan, Eman
    PHARMACEUTICAL RESEARCH, 2021, 38 (11) : 1821 - 1838
  • [6] Olmesartan niosomes ameliorates the Indomethacin-induced gastric ulcer in rats: Insights on MAPK and Nrf2/HO-1 signaling pathway
    Al-Aliaa M. Sallam
    Samar F. Darwish
    Walaa A. El-Dakroury
    Eman Radwan
    Pharmaceutical Research, 2021, 38 : 1821 - 1838
  • [7] CZ-7, a new derivative of Claulansine F, ameliorates 2VO-induced vascular dementia in rats through a Nrf2-mediated antioxidant responses
    Liu, Dan-dan
    Yuan, Xia
    Chu, Shi-feng
    Chen, Chen
    Ren, Qian
    Luo, Piao
    Lin, Mei-yu
    Wang, Sha-sha
    Zhu, Tian-bi
    Ai, Qi-di
    Zang, Ying-da
    Zhang, Dong-ming
    He, Xin
    Huang, Zhi-hua
    Sun, Hong-shuo
    Feng, Zhong-ping
    Chen, Nai-hong
    ACTA PHARMACOLOGICA SINICA, 2019, 40 (04) : 425 - 440
  • [8] CZ-7, a new derivative of Claulansine F, ameliorates 2VO-induced vascular dementia in rats through a Nrf2-mediated antioxidant responses
    Dan-dan Liu
    Xia Yuan
    Shi-feng Chu
    Chen Chen
    Qian Ren
    Piao Luo
    Mei-yu Lin
    Sha-sha Wang
    Tian-bi Zhu
    Qi-di Ai
    Ying-da Zang
    Dong-ming Zhang
    Xin He
    Zhi-hua Huang
    Hong-shuo Sun
    Zhong-ping Feng
    Nai-hong Chen
    Acta Pharmacologica Sinica, 2019, 40 : 425 - 440
  • [9] Albizzia chinensis (Osbeck) Merr extract YS ameliorates ethanol-induced acute gastric ulcer injury in rats by regulating NRF2 signaling pathway
    Tang, Bo
    Li, Liangning
    Yu, Yuanzhi
    Wang, Guibin
    Ma, Shuanggang
    Yu, Shishan
    Zhang, Jianjun
    ANIMAL MODELS AND EXPERIMENTAL MEDICINE, 2024, 7 (03) : 275 - 282
  • [10] Albizzia chinensis (Osbeck) Merr extract YS ameliorates ethanol-induced acute gastric ulcer injury in rats by regulating NRF2 signaling pathway
    Bo Tang
    Liangning Li
    Yuanzhi Yu
    Guibin Wang
    Shuanggang Ma
    Shishan Yu
    Jianjun Zhang
    Animal Models and Experimental Medicine, 2024, 7 (03) : 275 - 282