Remodel the perifollicular microenvironment via Minoxidil-loaded microneedle patch and cold atmospheric plasma for treating androgenetic alopecia

被引：2

作者：

Chen, Hao ^{[1
]}

Tang, Xianzhe ^{[1
]}

Huang, Yueye ^{[2
,3
]}

Chen, Chen ^{[1
]}

Yang, Yuheng ^{[1
]}

Hao, Chaojie ^{[1
]}

Xie, Wenqi ^{[1
]}

Huang, Tingjing ^{[1
]}

Cheng, Xiaofeng ^{[1
]}

Xu, Qingnan ^{[2
]}

Huang, Shicong ^{[3
]}

Ye, Zhi ^{[1
,4
]}

Lin, Xucong ^{[5
]}

Chen, Zhaowei ^{[1
,5
]}

Chen, Zhitong ^{[2
,3
,6
]}

机构：

[1] Fuzhou Univ, Coll Chem, New Cornerstone Sci Lab, MOE Key Lab Analyt Sci Food Safety & Biol, Fuzhou 350108, Peoples R China

[2] Chinese Acad Sci, Shenzhen Inst Adv Technol, Inst Biomed & Hlth Engn, Shenzhen 518055, Peoples R China

[3] Natl Innovat Ctr Adv Med Devices, Adv Therapeut Ctr, Shenzhen 518000, Peoples R China

[4] UCL, Dept Chem, London WC1H 0AJ, England

[5] Fuzhou Univ, Coll Chem, Engn Technol Res Ctr Reagent & Instrument Rapid De, Fuzhou 350108, Peoples R China

[6] Chinese Acad Sci, Key Lab Biomed Imaging Sci & Syst, Shenzhen 518055, Peoples R China

来源：

NANO RESEARCH | 2024年 / 17卷 / 07期

基金：

中国国家自然科学基金;

关键词：

nanomedicine; androgenetic alopecia; microneedle; cold atmospheric plasma; drug delivery; NITRIC-OXIDE; HAIR-GROWTH;

D O I：

10.1007/s12274-024-6619-0

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Androgenetic alopecia (AGA) is a chronic and progressive form of hair loss characterized by vascular degeneration in the perifollicular microenvironment, leading to cell apoptosis and eventual loss of hair follicles (HFs). Traditional therapeutic formulations, such as Minoxidil (MXD) tincture, have limitations in reshaping the perifollicular microenvironment and exhibit limited effectiveness. Here, we report a multi-synergistic therapeutic platform for high-performance hair regeneration therapy. The platform combines microneedle (MN) patches loaded with MXD-encapsulated nanostructured lipid carriers (MXD-NLC-MNs) and cold atmospheric plasma (CAP). The MNs' mechanical strength enables efficient transdermal delivery of MXD to the targeted dermal papilla cells, promoting cell proliferation. Furthermore, in collaboration with MXD, the mechanical stimulation exerted by MN application synergistically upregulates the expression of vascular endothelial growth factor, leading to neoangiogenesis. Meanwhile, the transient microchannels in the skin created by MNs facilitate the transdermal delivery of CAP-generated nitric oxide (NO) to the sites of HF lesions, whereby the synergistic interaction between MXD and NO boosts perifollicular vasodilation. Consequently, the perifollicular microenvironment can be effectively reshaped to accelerate hair regeneration in AGA murine models. This multi-synergistic combination therapy strategy would hold great promise for effectively treating AGA and promoting hair regrowth.

引用

页码：6411 / 6419

页数：9