Seven new 2-(2-phenethyl)chromone derivatives from agarwood of Aquilaria walla

被引：8

作者：

Chen, Leyao ^{[1
,2
]}

Chen, Huiqin ^{[2
]}

Cai, Caihong ^{[2
]}

Yuan, Jingzhe ^{[2
]}

Gai, Cuijuan ^{[2
]}

Liu, Shoubai ^{[1
]}

Mei, Wenli ^{[2
,3
]}

Dai, Haofu ^{[2
,3
]}

机构：

[1] Hainan Univ, Sch Forestry, Haikou 570228, Peoples R China

[2] Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Hainan Engn Res Ctr Agarwood, Haikou 571101, Peoples R China

[3] Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, 4 Xueyuan Rd, Haikou 571101, Hainan, Peoples R China

来源：

FITOTERAPIA | 2023年 / 165卷

关键词：

Aquilaria walla; Agarwood; Flavonoid-2-(2-phenylethyl)chromone; 2-(2-phenylethyl)chromone dimer; Cytotoxicity; DIMERIC 2-(2-PHENYLETHYL)CHROMONES; AGALWOOD JINKO;

D O I：

10.1016/j.fitote.2022.105421

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two rare flavonoid-2-(2-phenylethyl)chromones and five new dimeric 2-(2-phenylethyl)chromones were isolated from ethanol extract of agarwood of Aquilaria walla by LC-MS-guided fractionation procedure. Their structures were established based on extensive spectroscopic methods including HRESIMS, 1D and 2D NMR, as well as by comparison with the literature. Compound 1 showed cytotoxic activity against five human cancer cell lines with IC50 values ranging from 13.40 to 28.96 mu M with cisplatin as the positive control.

引用

页数：8

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