ASSOCIATING eNOS GENE VARIANTS WITH COVID-19 SUSCEPTIBILITY IN THE TURKISH POPULATION

被引:0
|
作者
Senkal, Naci [1 ]
Oyaci, Yasemin [2 ]
Cebeci, Timurhan [1 ]
Konyaoglu, Hilal [1 ]
Kose, Murat [1 ]
Onel, Mustafa [3 ]
Medetalibeyoglu, Alpay [1 ]
Sayin, Yesil Gozde [4 ]
Pehlivan, Mustafa [5 ]
Pehlivan, Sacide [2 ]
Isoglu-Alkac, Ummihan [6 ]
Tukek, Tufan [1 ]
机构
[1] Istanbul Univ, Istanbul Fac Med, Dept Internal Med, Istanbul, Turkiye
[2] Istanbul Univ, Istanbul Fac Med, Dept Med Biol, Istanbul, Turkiye
[3] Istanbul Univ, Istanbul Fac Med, Dept Microbiol, Istanbul, Turkiye
[4] Istanbul Univ, Istanbul Fac Med, Dept Med Genet, Istanbul, Turkiye
[5] Gaziantep Univ, Fac Med, Dept Haematol, Gaziantep, Turkiye
[6] Istanbul Univ, Istanbul Fac Med, Dept Physiol, Istanbul, Turkiye
关键词
COVID-19; nitric oxide synthase; variant; RFLP-PCR; NITRIC-OXIDE SYNTHASE; SMALL RNA; POLYMORPHISMS; DISEASES; LOCALIZATION; SEVERITY; IMPACT; T-786C; G894T;
D O I
10.26650/IUITFD.1211888
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: COVID-19 is a serious respiratory and vascular disease that impairs the protective function of the endothelial barrier. Endothelial nitric oxide synthase (eNOS), the most important isoform for NO production, is mostly expressed in endothelial cells. Therefore, this study aims to evaluate whether eNOS G894T and variable tandem repeat number (VNTR) functional variants show predisposition to developing COVID-19.Materials and Methods: The study includes a total of 384 subjects (284 COVID-19 patients and 100 healthy controls). Two eNOS gene variants (G894T and VNTR) were genotyped using the polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) methods, with the results being evaluated using statistical methods.Results: A significant association has been identified between eNOS G894T and COVID-19. For the eNOS G894T variant, the T/T genotype (p=0.035) and T allele carriers (p=0.030) appear to have an increased risk of developing COVID-19. The eNOS G894T G/G genotype (p=0.030) was more common in the control group compared to the patient group. No significant difference was found between groups regarding the eNOS VNTR genotype and allele frequencies (p>0.05). The genotypes of the patient and control groups for these variants were in Har-dy-Weinburg equilibrium (HWE).Conclusion: These results provide evidence supporting the hy-pothesis that the eNOS G894T variant is associated with an in-creased risk of developing COVID-19 in the Turkish population. These findings may lead to the emergence of new treatment op-tions. Further research is required to understand the molecular mechanisms involved in the pathogenesis of the disease.
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页码:1 / 6
页数:6
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