New Fusarin Derivatives from the Marine Algicolous Fungus Penicillium steckii SCSIO41040

被引：4
|
作者：
Song, Yingying [1 ,2 ]
She, Jianglian [1 ,2 ]
Chen, Weihao [1 ]
Wang, Jiamin [1 ,2 ]
Tan, Yanhui [3 ]
Pang, Xiaoyan [1 ]
Zhou, Xuefeng [1 ,2 ]
Wang, Junfeng [1 ,2 ]
Liu, Yonghong [1 ,2 ]
机构：
[1] Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, Guangzhou 510301, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
[3] Guangxi Normal Univ, Sch Chem & Pharmaceut Sci, State Key Lab Chem & Mol Engn Med Resources, Guilin 541004, Peoples R China
来源：
MARINE DRUGS | 2023年 / 21卷 / 10期
关键词：
fusarin derivatives; Penicillium steckii; marine algicolous fungus; HUMAN NEUROBLASTOMA-CELLS; EPOLACTAENE DERIVATIVES; CYCLE INHIBITOR; CANCER-CELLS; LUCILACTAENE; METABOLITES;
D O I：
10.3390/md21100532
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Five new fusarin derivatives, steckfusarins A-E (1-5), and two known natural products (6, 7), were isolated and identified from the marine algicolous fungus Penicillium steckii SCSIO 41040. The new compounds, including absolute configurations, were determined by spectroscopic analyses and calculated electronic circular dichroism (ECD). All new compounds were evaluated for their antioxidant, antibacterial, antifungal, antiviral, cytotoxic, anti-inflammatory, antioxidant, cholesterol-lowering, acetyl cholinesterase (AChE) enzyme and 6-phosphofructo-2-kinase (PFKFB3) and phosphatidylinositol-3-kinase (PI3K) inhibitory activities. The biological evaluation results revealed that compound 1 exhibited radical scavenging activity against 2,2-diphenyl-1-picrylhydrazylhydrate (DPPH), with an IC50 value of 74.5 mu g/mL. In addition, compound 1 also showed weak anti-inflammatory activity at a concentration of 20 mu M.
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页数：12
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