Supramolecular Conjugation between 18-Crown 6-Ether and Tannic Acid with Unique pH Responsiveness

被引：2
|
作者：
Endo, Saki [1 ]
Sara, Mahiro [1 ]
Hatano, Akihiko [2 ]
Niikura, Kenichi [1 ]
机构：
[1] Nippon Inst Technol, Fac Fundamental Engn, Dept Appl Chem, Miyashiro, Saitama 3458501, Japan
[2] Shibaura Inst Technol, Dept Mat Sci & Engn, Minuma ku, Saitama 3378570, Japan
来源：
CHEMISTRY LETTERS | 2023年 / 52卷 / 06期
关键词：
pH responsiveness; Tannic acid;
D O I：
10.1246/cl.230093
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We demonstrate that 18-crown 6-ether interacts with tannic acid to form particles at pH 7.4 that degrade at pH 5. Tannic acid has been used in biomaterials on conjugation with various polymers. However, there remains concern about the degrad-ability of such biomaterials. Although 18-crown 6-ether has a low molecular weight, the fact that it forms stable particles with tannic acid broadens the bioavailability of tannic acid. Furthermore, the pH-responsive properties under acidic con-ditions may favor drug release in lysosomes.
引用
收藏
页码：455 / 458
页数：4
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