Factors associated with swallowing dysfunction in patients with head and neck cancer

被引:2
|
作者
Vermaire, Jorine A. [1 ]
Raaijmakers, Cornelis P. J. [1 ]
Monninkhof, Evelyn M. [2 ]
Leeuw, Irma M. Verdonck-de [3 ,4 ,5 ]
Terhaard, Chris H. J. [1 ]
Speksnijder, Caroline M. [6 ,7 ]
机构
[1] Univ Utrecht, Univ Med Ctr Utrecht, Dept Radiat Oncol, Imaging Div, Utrecht, Netherlands
[2] Univ Utrecht, Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Dept Epidemiol, Utrecht, Netherlands
[3] Vrije Univ Amsterdam, Dept Otolaryngol Head & Neck Surg, Amsterdam UMC, Amsterdam, Netherlands
[4] Vrije Univ Amsterdam, Canc Ctr Amsterdam, Amsterdam UMC, Amsterdam, Netherlands
[5] Vrije Univ Amsterdam, Dept Clin Neuro & Dev Psychol, Amsterdam Publ Hlth Res Inst, Amsterdam, Netherlands
[6] Univ Utrecht, Univ Med Ctr Utrecht, Dept Oral & Maxillofacial Surg & Special Dent Car, Utrecht, Netherlands
[7] Univ Utrecht, Univ Med Ctr Utrecht, Dept Head & Neck Surg Oncol, Utrecht, Netherlands
关键词
100 ml water swallowing test; head and neck cancer; linear mixed model; swallowing dysfunction; RADIOTHERAPY; DYSPHAGIA; MANAGEMENT;
D O I
10.1111/odi.14192
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
Background: The aim of this prospective cohort study was to investigate swallowing function in relation to personal and clinical factors among patients with head and neck cancer (HNC) from diagnosis up to 2 years after treatment. Methods: The 100 ml water swallow test was measured before treatment, and 3, 6, 12, and 24 months after treatment. Linear mixed-effects model analysis was conducted to investigate changes over time and the association with personal (sex and age) and clinical (tumor site, tumor stage, and treatment modality) factors. Results: Among 128 included patients, number of swallows increased from baseline to 3 months after treatment and decreased to baseline again at 6 months after treatment. The number of swallows was associated with age and treatment modality. Conclusions In patients with HNC, swallowing (dys)function changes over time with the worst score 3 months after treatment. A higher age and being treated with surgery are factors associated with swallowing dysfunction over time.
引用
收藏
页码:1937 / 1946
页数:10
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