Therapeutic, Humanized Monoclonal Antibody Exhibits Broad Binding and Protective Efficacy against Acinetobacter baumannii

被引：5
|
作者：
Slarve, Matthew [1 ]
Reyna, Zeferino [1 ]
Burk, Elizabeth [1 ]
Ruiz-Delgado, Juan [1 ]
Li, Rachel [1 ]
Yan, Jun [1 ]
Luna, Brian [1 ]
Spellberg, Brad [2 ]
机构：
[1] Keck Sch Med USC, Dept Mol Microbiol & Immunol, Los Angeles, CA 90033 USA
[2] Angeles Cty USC LACUSC Med Ctr, Los Angeles, CA USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2023年 / 67卷 / 03期
关键词：
Acinetobacter baumannii; K antigen; monoclonal antibody; O antigen; antibiotic resistance; carbohydrates; therapeutic;
D O I：
10.1128/aac.00086-23
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Acinetobacter baumannii is an extremely drug-resistant pathogen necessitating the development of new therapies. We seek to generate a cocktail of monoclonal antibodies (MAbs) that can target the full diversity of A. baumannii isolates. We have newly identified the antibody MAb5. Here, we demonstrate that MAb5 has broad binding against U.S. (n = 300) and international (n = 250) isolates (72.24% and 28.76%, respectively), likely targets O-antigen capsular carbohydrates, and exhibits protective efficacy in vivo. Acinetobacter baumannii is an extremely drug-resistant pathogen necessitating the development of new therapies. We seek to generate a cocktail of monoclonal antibodies (MAbs) that can target the full diversity of A. baumannii isolates.
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页数：6
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