Clonal haematopoiesis and atherosclerotic cardiovascular disease

被引：2
|
作者：
Ahmad, Herra [1 ,2 ]
Jaiswal, Siddhartha [3 ,4 ]
机构：
[1] Stanford Univ, Dept Pathol, Stanford, CA USA
[2] Charite, Dept Cardiol, Berlin, Germany
[3] Stanford Univ, Stanford Cardiovasc Inst, Stanford, CA 94305 USA
[4] Stanford Univ, Inst Stem Cell Biol & Regenerat Med, Stanford, CA 94305 USA
来源：
NATURE REVIEWS CARDIOLOGY | 2023年 / 20卷 / 07期
关键词：
D O I：
10.1038/s41569-023-00882-2
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Clonal haematopoiesis of indeterminate potential (CHIP) is defined as an expansion of mutant blood stem cells in individuals without haematological malignancies. CHIP is linked to an increased risk of non-cancerous disorders such as atherosclerotic cardiovascular disease, possibly because mutant innate immune cells have pro-inflammatory phenotypes. Prospective studies are needed to determine whether individuals with CHIP might benefit from anti-inflammatory therapies.
引用
收藏
页码：437 / 438
页数：2
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