Discovery of Anti-Inflammatory Triterpenoid Glucosides from the Heritiera littoralis Dryand

被引：5
|
作者：
Liang, Xiaoqin [1 ,2 ]
Niu, Peng [1 ]
Li, Jun [2 ]
Guan, Xinlan [3 ]
Zhang, Yanjun [1 ]
Li, Jian [3 ]
机构：
[1] Beibu Gulf Univ, Coll Petr & Chem Engn, Guangxi Key Lab Green Chem Mat & Safety Technol, Qinzhou 535000, Peoples R China
[2] Guangxi Normal Univ, Sch Chem & Pharmaceut Sci, State Key Lab Chem & Mol Engn Med Resources, Guilin 541004, Peoples R China
[3] Peoples Hosp Pubei, Qinzhou 535300, Peoples R China
来源：
MOLECULES | 2023年 / 28卷 / 04期
关键词：
Heritiera littoralis Dryand; Heritiera A; Heritiera B; anti-inflammatory; SAPONINS; ACID; L;
D O I：
10.3390/molecules28041658
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Two new triterpenoid glucosides, Heritiera A (1) and Heritiera B (2), and six known triterpenoid analogs (3-8) were isolated from Heritiera littoralis Dryand. Their structures were identified by comprehensive spectroscopic analyses and comparisons with the literature. The anti-inflammatory activity of the isolates from H. littoralis was evaluated using a lipopolysaccharide (LPS) stimulated RAW 264.7 cells model. The result showed that four triterpenoids exhibited potent anti-inflammatory activity. Among these compounds, compound 2 substantially inhibits the release of nitric oxide (NO) with an IC50 value of 10.33 mu M. The triterpenoids from H. littoralis could be used as potential candidates for the development of new anti-inflammatory agents.
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页数：11
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