HiOmics: A cloud-based one-stop platform for the comprehensive analysis of large-scale omics data

被引:0
|
作者
Li, Wen [1 ,2 ,3 ]
Zhang, Zhining [4 ]
Xie, Bo [1 ]
He, Yunlin [4 ]
He, Kangming [4 ]
Qiu, Hong [1 ,4 ]
Lu, Zhiwei [4 ]
Jiang, Chunlan [4 ]
Pan, Xuanyu [5 ]
He, Yuxiao [1 ]
Hu, Wenyu [4 ]
Liu, Wenjian [6 ]
Que, Tengcheng [6 ,7 ,8 ]
Hu, Yanling [1 ,2 ,3 ,4 ,6 ]
机构
[1] Guangxi Med Univ, Life Sci Inst, Nanning, Guangxi, Peoples R China
[2] Guangxi Med Univ, Sch Basic Med, Dept Biochem & Mol Biol, Nanning, Guangxi, Peoples R China
[3] Guangxi Med Univ, Educ Dept Guangxi Zhuang Autonomous Reg, Key Lab Biol Mol Med Res, Nanning, Guangxi, Peoples R China
[4] Guangxi Henbio Biotechnol Co Ltd, Nanning, Guangxi, Peoples R China
[5] Guangxi Med Univ, Sch Basic Med, Nanning, Guangxi, Peoples R China
[6] City Univ Macau, Fac Data Sci, Macau, Peoples R China
[7] Youjiang Med Univ Nationalities, Baise, Guangxi, Peoples R China
[8] Guangxi Zhuang Autonomous Terr Wildlife Rescue Res, Nanning, Guangxi, Peoples R China
基金
中国国家自然科学基金;
关键词
Artificial intelligence modeling; Cloud-based analysis; HiOmics; Large-scale omics data analysis; Multi-omics integration analysis; BIOINFORMATICS;
D O I
10.1016/j.csbj.2024.01.002
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Analyzing the vast amount of omics data generated comprehensively by high-throughput sequencing technology is of utmost importance for scientists. In this context, we propose HiOmics, a cloud-based platform equipped with nearly 300 plugins designed for the comprehensive analysis and visualization of omics data. HiOmics utilizes the Element Plus framework to craft a user-friendly interface and harnesses Docker container technology to ensure the reliability and reproducibility of data analysis results. Furthermore, HiOmics employs the Workflow Description Language and Cromwell engine to construct workflows, ensuring the portability of data analysis and simplifying the examination of intricate data. Additionally, HiOmics has developed DataCheck, a tool based on Golang, which verifies and converts data formats. Finally, by leveraging the object storage technology and batch computing capabilities of public cloud platforms, HiOmics enables the storage and processing of large-scale data while maintaining resource independence among users.
引用
收藏
页码:659 / 668
页数:10
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