Cp*Rh(III)-Catalyzed ortho-Alkylation/Alkenylation of Nitroarenes

被引：6

作者：

Xiao, Lin ^{[1
]}

Liu, Xu-Ge ^{[2
]}

Bao, Mei-Zhu ^{[1
]}

Song, Jia-Lin ^{[1
]}

Chen, Shao-Yong ^{[1
]}

Zheng, Yi-Chuan ^{[1
]}

Liu, Yan-Zhi ^{[1
]}

Zhang, Shang-Shi ^{[1
]}

机构：

[1] Guangdong Pharmaceut Univ, Ctr Drug Res & Dev, Guangdong Prov Engn Ctr Top Precise Drug Delivery, Guangdong Prov Key Lab Adv Drug Delivery, Guangzhou 510006, Peoples R China

[2] Henan Univ, Sch Pharm, Kaifeng 475004, Henan, Peoples R China

来源：

ORGANIC LETTERS | 2023年 / 25卷 / 28期

基金：

中国国家自然科学基金;

关键词：

C-H ACTIVATION; ANILINE N-OXIDES; FUNCTIONALIZATIONS; COMBINATION; ANNULATION; ALKYNES;

D O I：

10.1021/acs.orglett.3c01614

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Cp*Rh(III)-catalyzednitro-directed C-H alkylation/alkenylationof nitroarenes has been reported for the first time. This protocolis associated with the features of high efficiency, broad substratescope, and good functional group compatibility. Additionally, gram-scaleexperiments and synthetic applications proved the practicability ofthe method. Moreover, preliminary mechanistic investigations consistentlyrevealed C-H bond cleavage as the rate-limiting step.

引用

页码：5185 / 5190

页数：6

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