Highly chemoselective transfer hydrogenation of the C--C bonds of α-Keto substituted acrylate compounds catalyzed by an Iridium-TsEN complex in water

被引：1

作者：

Ahmad, Ala ^{[1
]}

Wong, Crystal ^{[1
]}

Chapin, Jordan ^{[1
]}

Ni, Bukuo ^{[1
]}

机构：

[1] Texas A&M Univ Commerce, Dept Chem, Commerce, TX 75429 USA

来源：

TETRAHEDRON LETTERS | 2024年 / 135卷

关键词：

Chemoselective; Transfer hydrogenation; Catalysis; C =C bonds; Acrylate; ASYMMETRIC TRANSFER HYDROGENATION; CLAISEN CONDENSATION; MICHAEL ADDITION; BLAISE REACTION; EFFICIENT; ORGANOCATALYST; INHIBITORS; ANALOGS; ESTERS;

D O I：

10.1016/j.tetlet.2023.154904

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Highly chemoselective transfer hydrogenation of the C--C bonds of alpha-keto substituted acrylate compounds catalyzed by an [IrCl2Cp*]2-TsEN Complex (Cp* = q5-C5Me5) in water using sodium formate as hydride source has been developed. A variety of alpha-keto substituted acrylate compounds were reduced smoothly under 0.5 mol% of Iridium catalyst with 1.0 mol% ligand TsEN and 3 equiv. of sodium formate providing the desired product alpha-alkyl-beta-keto esters in high to excellent yields (80-99 %). The procedure presented is simple and makes this method suitable for practical use.

引用

页数：5

共 11 条

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