Polyphenols in Oral Health: Homeostasis Maintenance, Disease Prevention, and Therapeutic Applications

被引:14
|
作者
Guo, Yuanyuan [1 ,2 ,3 ]
Li, Zhiquan [4 ]
Chen, Feng [5 ]
Chai, Yujuan [1 ]
机构
[1] Shenzhen Univ, Med Sch, Sch Biomed Engn, Shenzhen 518060, Peoples R China
[2] Shenzhen Univ, Coll Phys & Optoelect Engn, Key Lab Optoelect Devices & Syst, Shenzhen 518060, Peoples R China
[3] Shenzhen Univ, Sch Biomed Engn, Guangdong Key Lab Biomed Measurements & Ultrasound, Natl Reg Key Technol Engn Lab Med Ultrasound,Med S, Shenzhen 518060, Peoples R China
[4] Univ Copenhagen, Ctr Hlth Aging, Dept Cellular & Mol Med, DK-2200 Copenhagen, Denmark
[5] Peking Univ, Sch & Hosp Stomatol, Cent Lab, Beijing 100081, Peoples R China
关键词
polyphenols; oral microbiota; functional food; oral caries; periodontal diseases; halitosis; oral cancer; BLACK TEA POLYPHENOLS; STREPTOCOCCUS-MUTANS; GREEN TEA; ANTIBACTERIAL ACTIVITY; CRANBERRY COMPONENTS; METABOLIZING-ENZYMES; GLOBAL BURDEN; IN-VITRO; KAPPA-B; MODULATION;
D O I
10.3390/nu15204384
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Polyphenols, a class of bioactive compounds with phenolic structures, are abundant in human diets. They have gained attention in biomedical fields due to their beneficial properties, including antioxidant, antibacterial, and anti-inflammatory activities. Therefore, polyphenols can prevent multiple chronic or infectious diseases and may help in the prevention of oral diseases. Oral health is crucial to our well-being, and maintaining a healthy oral microbiome is essential for preventing various dental and systemic diseases. However, the mechanisms by which polyphenols modulate the oral microbiota and contribute to oral health are still not fully understood, and the application of polyphenol products lies in different stages. This review provides a comprehensive overview of the advancements in understanding polyphenols' effects on oral health: dental caries, periodontal diseases, halitosis, and oral cancer. The mechanisms underlying the preventive and therapeutic effects of polyphenols derived from dietary sources are discussed, and new findings from animal models and clinical trials are included, highlighting the latest achievements. Given the great application potential of these natural compounds, novel approaches to dietary interventions and oral disease treatments may emerge. Moreover, investigating polyphenols combined with different materials presents promising opportunities for developing innovative therapeutic strategies in the treatment of oral diseases.
引用
收藏
页数:32
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