Tumor Molecular Profiling Using an Amplicon-Based Next-Generation Sequencing Assay Reveals That Low Tumor Cellularity Is the Major Limitation in Detecting Gene Amplification

被引:0
|
作者
Chan, Danny [1 ]
Lin, August [1 ]
Craddock, Kenneth [2 ]
Goswami, Rashmi [1 ]
Hwang, David [3 ]
Huang, Weei-Yuarn [1 ]
机构
[1] Sunnybrook Hlth Sci Ctr, Toronto, ON, Canada
[2] Univ Toronto, Sunnybrook Hlth Sci Ctr, Toronto, ON, Canada
[3] Sunnybrook Hlth Sci Ctr, Toronto, ON, Canada
关键词
D O I
暂无
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
1424
引用
收藏
页码:S1543 / S1543
页数:1
相关论文
共 50 条
  • [1] Multicentric evaluation of amplicon-based next-generation sequencing solution for local comprehensive molecular tumor profiling
    Jantus Lewintre, E.
    Rappa, A.
    Ruano, D.
    Gallach Garcia, S.
    Camps Herrero, C. J. C.
    Lacroix, L.
    Kashofer, K.
    van Wezel, T.
    Barberis, M.
    ANNALS OF ONCOLOGY, 2023, 34 : S269 - S269
  • [2] Clinical Validation of an Amplicon-Based Next-Generation Sequencing Assay for Myeloid Malignancies
    Oultache, A.
    Nafa, K.
    Chen, W. J.
    Mensah, N. T.
    Mitchell, T. N.
    Syed, A.
    Zehir, A.
    Cheng, D.
    Arcila, M. E.
    Levine, R. L.
    Berger, M. F.
    Hedvat, C. V.
    JOURNAL OF MOLECULAR DIAGNOSTICS, 2013, 15 (06): : 861 - 862
  • [3] Identification of clinically relevant alterations in phyllodes tumor of the breast by amplicon-based next-generation sequencing
    Julia Y. S. Tsang
    Edna May L. Go
    Gary M. Tse
    Breast Cancer Research and Treatment, 2015, 151 : 717 - 719
  • [4] Identification of clinically relevant alterations in phyllodes tumor of the breast by amplicon-based next-generation sequencing
    Tsang, Julia Y. S.
    Go, Edna May L.
    Tse, Gary M.
    BREAST CANCER RESEARCH AND TREATMENT, 2015, 151 (03) : 717 - 719
  • [5] Clinical relevance of circulating tumor DNA assessed through amplicon-based next-generation sequencing
    Zembutsu, Hitoshi
    CANCER SCIENCE, 2018, 109 : 1076 - 1076
  • [6] Multicenter In-House Evaluation of an Amplicon-Based Next-Generation Sequencing Panel for Comprehensive Molecular Profiling
    Jantus-Lewintre, Eloisa
    Rappa, Alessandra
    Ruano, Dina
    van Egmond, Demi
    Gallach, Sandra
    Gozuyasli, Dilce
    Duraes, Cecilia
    Costa, Jose Luis
    Camps, Carlos
    Lacroix, Ludovic
    Kashofer, Karl
    van Wezel, Tom
    Barberis, Massimo
    MOLECULAR DIAGNOSIS & THERAPY, 2025, 29 (02) : 249 - 261
  • [7] Amplicon-based next-generation sequencing: an effective approach for the molecular diagnosis of epidermolysis bullosa
    Tenedini, E.
    Artuso, L.
    Bernardis, I.
    Artusi, V.
    Percesepe, A.
    De Rosa, L.
    Contin, R.
    Manfredini, R.
    Pellacani, G.
    Giannetti, A.
    Pagani, J.
    De Luca, M.
    Tagliafico, E.
    BRITISH JOURNAL OF DERMATOLOGY, 2015, 173 (03) : 731 - 738
  • [8] Analytical and clinical validation of an amplicon-based next generation sequencing assay for ultrasensitive detection of circulating tumor DNA
    Poh, Jonathan
    Ngeow, Kao Chin
    Pek, Michelle
    Tan, Kian-Hin
    Lim, Jing Shan
    Chen, Hao
    Ong, Choon Kiat
    Lim, Jing Quan
    Lim, Soon Thye
    Lim, Chwee Ming
    Goh, Boon Cher
    Choudhury, Yukti
    PLOS ONE, 2022, 17 (04):
  • [9] Adaptation of an amplicon-based human cancer next-generation sequencing panel assay for murine tumors
    Meier, David R.
    Lofgren, Kristopher A.
    Gurda, Grzegorz T.
    Kenny, Paraic A.
    ANALYTICAL BIOCHEMISTRY, 2018, 551 : 26 - 28
  • [10] Performance of amplicon-based next generation DNA sequencing for diagnostic gene mutation profiling in oncopathology
    Daoud Sie
    Peter J.F. Snijders
    Gerrit A. Meijer
    Marije W. Doeleman
    Marinda I. H. van Moorsel
    Hendrik F. van Essen
    Paul P. Eijk
    Katrien Grünberg
    Nicole C. T. van Grieken
    Erik Thunnissen
    Henk M. Verheul
    Egbert F. Smit
    Bauke Ylstra
    Daniëlle A. M. Heideman
    Cellular Oncology, 2014, 37 : 353 - 361