A road map for the treatment of pediatric diffuse midline glioma

被引：5

作者：

Koschmann, Carl ^{[1
]}

Al-Holou, Wajd N. ^{[1
]}

Alonso, Marta M. ^{[2
]}

Anastas, Jamie ^{[3
]}

Bandopadhayay, Pratiti ^{[4
]}

Barron, Tara ^{[5
]}

Becher, Oren ^{[6
]}

Cartaxo, Rodrigo ^{[1
]}

Castro, Maria G. ^{[1
]}

Chung, Chan ^{[7
]}

Clausen, Madison ^{[1
]}

Dang, Derek ^{[1
]}

Doherty, Robert ^{[1
]}

Duchatel, Ryan ^{[8
]}

Dun, Matthew ^{[8
]}

Filbin, Mariella ^{[4
]}

Franson, Andrea ^{[1
]}

Galban, Stefanie ^{[1
]}

Moure, Marc Garcia ^{[2
]}

Garton, Hugh ^{[1
]}

Gowda, Pruthvi ^{[4
]}

Marques, Joana Graca ^{[2
]}

Hawkins, Cynthia ^{[9
]}

Heath, Allison ^{[10
]}

Hulleman, Esther ^{[11
]}

Ji, Sunjong ^{[1
]}

Jones, Chris ^{[12
]}

Kilburn, Lindsay ^{[13
]}

Kline, Cassie ^{[10
]}

Koldobskiy, Michael A. ^{[14
]}

Lim, Daniel ^{[1
]}

Lowenstein, Pedro R. ^{[1
]}

Lu, Q. Richard ^{[16
,17
]}

Lum, Joanna ^{[1
]}

Mack, Stephen ^{[18
]}

Magge, Suresh ^{[1
]}

Marini, Bernard ^{[1
]}

Messinger, Dana ^{[1
]}

Martin, Donna ^{[1
]}

Marupudi, Neena ^{[1
]}

Mody, Rajen ^{[1
]}

Morgan, Meredith ^{[1
]}

Mota, Mateus ^{[1
]}

Muraszko, Karin ^{[1
]}

Mueller, Sabine ^{[15
,19
]}

Natarajan, Siva Kumar ^{[1
]}

Nazarian, Javad ^{[13
,31
]}

Niculcea, Michael ^{[1
]}

Nuechterlein, Nicholas ^{[1
,20
]}

Okada, Hideho ^{[1
,15
]}

机构：

[1] Univ Michigan, Ann Arbor, MI 48109 USA

[2] Clin Univ Navarra, Navarra, Spain

[3] Baylor Coll Med, Houston, TX 77030 USA

[4] Dana Faber Canc Inst, Boston, MA 02215 USA

[5] Stanford Univ, Stanford, CA 94305 USA

[6] Icahn Sch Med Mt Sinai, New York, NY 10029 USA

[7] Daegu Gyeongbuk Inst Sci & Technol, Daegu 42988, South Korea

[8] Univ Newcastle, Callaghan, NSW 2308, Australia

[9] Hosp Sick Children, Toronto, ON M5G 1E8, Canada

[10] Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA

[11] Princess Maxima Ctr, NL-3584 CS Utrecht, Netherlands

[12] Inst Canc Res, Div Mol Pathol, London SM2 5NG, England

[13] Childrens Natl Hosp, Washington, DC 20010 USA

[14] Johns Hopkins Univ, Baltimore, MD 21205 USA

[15] Univ Calif San Francisco, San Francisco, CA 94143 USA

[16] Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH 45229 USA

[17] Univ Cincinnati, Cincinnati, OH 45229 USA

[18] St Jude, Memphis, TN 38105 USA

[19] Univ Zurich, Parker Inst Canc Immunotherapy, Zurich, Switzerland

[20] NIH, Bldg 10, Bethesda, MD 20892 USA

[21] Duke Univ, Durham, NC 27708 USA

[22] Advocate Childrens Hosp, Park Ridge, IL 60068 USA

[23] Weill Cornell Med, New York Presbyterian, New York, NY 10065 USA

[24] Mem Sloan Kettering Canc Ctr, New York, NY 10065 USA

[25] Columbia Univ, Herbert Irving Comprehens Canc Ctr, Med Ctr, Dept Neurol, New York, NY 10032 USA

[26] Columbia Univ, Dept Neurol, Med Ctr, New York, NY 10032 USA

[27] Univ Colorado Denver, Denver, CO 80204 USA

[28] Univ New South Wales, Fac Med & Hlth, Sch Biomed Sci, Sydney, NSW, Australia

[29] Sanford Burnham Prebys Med Discovery Inst, La Jolla, CA 92037 USA

[30] Childrens Mercy, Kansas City, MO 64108 USA

[31] Univ Zurich, Zurich, Switzerland

来源：

CANCER CELL | 2024年 / 42卷 / 01期

基金：

美国国家卫生研究院;

关键词：

HIGH-GRADE; CELLS; GAIN;

D O I：

10.1016/j.ccell.2023.11.002

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recent clinical trials for H3K27-altered diffuse midline gliomas (DMGs) have shown much promise. We present a consensus roadmap and identify three major barriers: (1) refinement of experimental models to include immune and brain-specific components; (2) collaboration among researchers, clinicians, and industry to integrate patient-derived data through sharing, transparency, and regulatory considerations; and (3) streamlining clinical efforts including biopsy, CNS-drug delivery, endpoint determination, and response monitoring. We highlight the importance of comprehensive collaboration to advance the understanding, diagnostics, and therapeutics for DMGs.

引用

页码：1 / 5

页数：5

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