Super-Stable Homogeneously Sustained-Release System Mediates Transcatheter Arterial Ionic-Embolization Strategy for Hepatocellular Carcinoma Therapy

被引：1

作者：

Peng, Xuqi ^{[1
]}

Zheng, Yating ^{[1
]}

Xue, Yi ^{[2
]}

Liang, Xiaoliu ^{[1
]}

He, Pan ^{[1
,3
]}

Chen, Hu ^{[1
]}

He, Peng ^{[1
]}

Peng, Yisheng ^{[1
]}

Zhao, Zhenwen ^{[1
]}

Chen, Yulun ^{[1
]}

Gui, Xiran ^{[1
]}

Yang, Lei ^{[1
]}

Xiong, Yongfu ^{[3
]}

Lin, Juan ^{[4
]}

Shi, Yesi ^{[1
]}

Chu, Chengchao ^{[1
,5
]}

Zhang, Yang ^{[1
,6
,7
,8
]}

Liu, Gang ^{[1
]}

机构：

[1] Xiamen Univ, Ctr Mol Imaging & Translat Med, Sch Publ Hlth, State Key Lab Vaccines Infect Dis,Xiang Biomed Lab, Xiamen 361002, Peoples R China

[2] Xiamen Univ, Sch Med, Xiangan Hosp, Dept Burns & Plast & Wound Repair Surg, Xiamen 361102, Peoples R China

[3] North Sichuan Med Coll, Affiliated Hosp, Academician Expert Workstat, Dept Hepatobiliary Surg, Nanchong 637600, Peoples R China

[4] Xiamen Univ, Chinese Acad Med Sci, Canc Res Ctr, Sch Med,Res Unit Cellular Stress, Xiamen 361102, Peoples R China

[5] Xiamen Univ, Eye Inst, Sch Med, Fujian Prov Key Lab Ophthalmol & Visual Sci, Xiamen 361102, Peoples R China

[6] Xiamen Univ, Shen Zhen Res Inst, Shenzhen 518057, Peoples R China

[7] Harvard Med Sch, Ctr Nanomed, Boston, MA 02115 USA

[8] Harvard Med Sch, Brigham & Womens Hosp, Dept Anesthesiol Perioperat & Pain Med, Boston, MA 02115 USA

来源：

ADVANCED FUNCTIONAL MATERIALS | 2024年 / 34卷 / 11期

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

hepatocellular carcinoma; NaCl particles; transcatheter arterial ionic-embolization; lipiodol; SHIFT; TACE; EFFICACY; SODIUM; TRANSPORTERS; METASTASIS; APOPTOSIS; APATINIB;

D O I：

10.1002/adfm.202311505

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The clinical effectiveness of locoregional therapies in treating hepatocellular carcinoma (HCC) is frequently constrained by multi-drug resistance and/or tumor metastasis. To surmount these challenges, a promising approach, transcatheter arterial ionic-embolization (TAIE) is proposed, which can specifically and continuously disrupt the intracellular ionic balance to significantly inhibit tumor activity and invasion. The hydrophilic micro-nanoscale sodium chloride particles (SCPs) are ingeniously intermixed with hydrophobic lipiodol to create a super-stable homogeneous embolic formulation (lipiodol-sodium chloride, LSC). After interventional administration, the LSC selectively deposits in HCC lesions, where lipiodol stably delivers SCPs to disrupt the cell's ionic balance, causing cell death without drug resistance. Notably, it is demonstrated that LSC can significantly hinder tumor cell migration and invasion. The mechanism is through SCP disruption of the ionic balance, which induces cell swelling and subsequent vimentin hydrolysis-mediated cytoskeletal remodeling. In addition, it is found that LSC treatment notably downregulates the expression of MYLK, TLN, and THBS2 genes in the focal adhesion (FA) signaling pathway of HepG2 cells. LSC formulation integrated tumor-specific deposition, intratumoral sustained release, efficient tumoricidal activity, significant metastasis inhibition, and excellent biological safety, thereby demonstrating superior in vivo tumor therapeutic effects via TAIE strategy, and showing a promising cancer therapeutic approach for clinical application. A promising strategy involving a super-stable homogeneously sustained-release system mediates transcatheter arterial ionic embolization (TAIE). It integrates tumor-specific deposition, intratumoral sustained release, efficient tumoricidal activity, significant metastasis inhibition, and excellent biological safety. This approach consistently demonstrates superior in vivo tumor therapeutic effects and holds potential as a viable cancer therapeutic method for clinical application.image

引用

页数：18

共 1 条

[1] Suitable blending method of lipiodol-cisplatin in transcatheter arterial embolization for hepatocellular carcinoma: Evaluation of sustained release and accumulation nature
Takaki, Yasunobu
Kaminou, Toshio
Shabana, Masanobu
Ihaya, Takashi
Otsubo, Kenji
Ogawa, Toshihide
HEPATO-GASTROENTEROLOGY, 2008, 55 (81) : 202 - 206

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