New pieces for the Lis1-dynein puzzle

被引：0
|
作者：
Lau, Clinton K. [1 ]
机构：
[1] Univ Oxford, Dept Biochem, Oxford, England
来源：
NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2023年 / 30卷 / 09期
基金：
英国惠康基金;
关键词：
DYNEIN;
D O I：
10.1038/s41594-023-01084-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The microtubule motor dynein is regulated by lissencephaly-1 (Lis1) at several points during its complex activation process. Two papers reveal the molecular mechanism for two steps: the beginning, when Lis1 acts as a wedge to disrupt dynein's autoinhibited conformation; and the end, when microtubule binding ejects Lis1 from the motor.
引用
收藏
页码：1244 / 1246
页数：3
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