Clinicopathological characteristics of early gastric cancer with different level of undifferentiated component and nomogram to predict lymph node metastasis
被引:2
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作者:
Li, Chenyu
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Dalian Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Dalian, Peoples R ChinaDalian Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Dalian, Peoples R China
Li, Chenyu
[1
]
Xie, Suling
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Dalian Med Univ, Affiliated Hosp 1, Dept Pathol, Dalian, Peoples R ChinaDalian Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Dalian, Peoples R China
Xie, Suling
[2
]
Chen, Dan
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机构:
Dalian Med Univ, Affiliated Hosp 1, Dept Pathol, Dalian, Peoples R ChinaDalian Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Dalian, Peoples R China
Chen, Dan
[2
]
Zhang, Jingwen
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机构:
Dalian Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Dalian, Peoples R China
Dalian Med Univ, Affiliated Hosp 1, Dept Pathol, Dalian, Peoples R ChinaDalian Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Dalian, Peoples R China
Zhang, Jingwen
[1
,2
]
Zhang, Ning
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机构:
Dalian Med Univ, Affiliated Hosp 1, Dept Geriatr Med, Dalian, Peoples R ChinaDalian Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Dalian, Peoples R China
Zhang, Ning
[3
]
Mu, Jinchao
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Dalian Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Dalian, Peoples R ChinaDalian Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Dalian, Peoples R China
Mu, Jinchao
[1
]
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Gong, Aixia
[1
]
机构:
[1] Dalian Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Dalian, Peoples R China
[2] Dalian Med Univ, Affiliated Hosp 1, Dept Pathol, Dalian, Peoples R China
[3] Dalian Med Univ, Affiliated Hosp 1, Dept Geriatr Med, Dalian, Peoples R China
BackgroundFew studies showed that mixed type early gastric cancer (EGC) relates to higher risk of lymph node metastasis. We aimed to explore the clinicopathological feature of GC according to different proportions of undifferentiated components (PUC) and develop a nomogram to predict status of lymph node metastasis (LNM) in EGC lesions. MethodsClinicopathological data of the 4,375 patients who underwent surgically resection for gastric cancer in our center were retrospectively evaluated and finally 626 cases were included. We classified mixed type lesions into five groups (M1:0% < PUC <= 20%, M2:20%<PUC <= 40%, M3:40%<PUC <= 60%, M4:60%<PUC <= 80%, M5:80%<PUC < 100%). Lesions with 0% PUC were classified as pure differentiated group (PD) and lesions with 100% PUC were classified as pure undifferentiated group (PUD). ResultsCompared with PD, LNM rate was higher in group M4 and group M5 (p < 0.05 after Bonferroni correction). Differences of tumor size, presence of lymphovascular invasion (LVI), perineural invasion and invasion depth also exist between groups. No statistical difference of LNM rate was found in cases who met the absolute endoscopic submucosal dissection (ESD) indications for EGC patients. Multivariate analysis revealed that tumor size over 2 cm, submucosa invasion to SM2, presence of LVI and PUC level M4 significantly predicted LNM in EGC. With the AUC of 0.899(P < 0.05), the nomogram exhibited a good discrimination. Internal validation by Hosmer-Lemeshow test showed a good fitting effect in model (P > 0.05). ConclusionPUC level should be considered as one of the predicting risk factors of LNM in EGC. A nomogram that predicts the risk of LNM in EGC was developed.
机构:
Chinese Acad Med Sci, Canc Hosp, Natl Canc Center, Dept Abdominal Surg Oncol, Beijing, Peoples R China
Peking Union Med Coll, Canc Hosp, Natl Canc Center, Dept Abdominal Surg Oncol, Beijing, Peoples R ChinaChinese Acad Med Sci, Canc Hosp, Natl Canc Center, Dept Abdominal Surg Oncol, Beijing, Peoples R China
Guo, Chun Guang
Zhao, Dong Bing
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机构:
Chinese Acad Med Sci, Canc Hosp, Natl Canc Center, Dept Abdominal Surg Oncol, Beijing, Peoples R China
Peking Union Med Coll, Canc Hosp, Natl Canc Center, Dept Abdominal Surg Oncol, Beijing, Peoples R ChinaChinese Acad Med Sci, Canc Hosp, Natl Canc Center, Dept Abdominal Surg Oncol, Beijing, Peoples R China
Zhao, Dong Bing
Liu, Qian
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机构:
Chinese Acad Med Sci, Canc Hosp, Natl Canc Center, Dept Abdominal Surg Oncol, Beijing, Peoples R China
Peking Union Med Coll, Canc Hosp, Natl Canc Center, Dept Abdominal Surg Oncol, Beijing, Peoples R ChinaChinese Acad Med Sci, Canc Hosp, Natl Canc Center, Dept Abdominal Surg Oncol, Beijing, Peoples R China
Liu, Qian
Zhou, Zhi Xiang
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机构:
Chinese Acad Med Sci, Canc Hosp, Natl Canc Center, Dept Abdominal Surg Oncol, Beijing, Peoples R China
Peking Union Med Coll, Canc Hosp, Natl Canc Center, Dept Abdominal Surg Oncol, Beijing, Peoples R ChinaChinese Acad Med Sci, Canc Hosp, Natl Canc Center, Dept Abdominal Surg Oncol, Beijing, Peoples R China
Zhou, Zhi Xiang
Zhao, Ping
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机构:
Chinese Acad Med Sci, Canc Hosp, Natl Canc Center, Dept Abdominal Surg Oncol, Beijing, Peoples R China
Peking Union Med Coll, Canc Hosp, Natl Canc Center, Dept Abdominal Surg Oncol, Beijing, Peoples R ChinaChinese Acad Med Sci, Canc Hosp, Natl Canc Center, Dept Abdominal Surg Oncol, Beijing, Peoples R China
Zhao, Ping
Wang, Gui Qi
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机构:
Chinese Acad Med Sci, Canc Hosp, Natl Canc Center, Dept Endoscopy, Beijing, Peoples R China
Peking Union Med Coll, Canc Hosp, Natl Canc Center, Dept Endoscopy, Beijing, Peoples R ChinaChinese Acad Med Sci, Canc Hosp, Natl Canc Center, Dept Abdominal Surg Oncol, Beijing, Peoples R China
Wang, Gui Qi
Cai, Jian Qiang
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机构:
Chinese Acad Med Sci, Canc Hosp, Natl Canc Center, Dept Abdominal Surg Oncol, Beijing, Peoples R China
Peking Union Med Coll, Canc Hosp, Natl Canc Center, Dept Abdominal Surg Oncol, Beijing, Peoples R ChinaChinese Acad Med Sci, Canc Hosp, Natl Canc Center, Dept Abdominal Surg Oncol, Beijing, Peoples R China
机构:
Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Canc Ctr, Guangzhou 510060, Peoples R China
Sun Yat Sen Univ, Dept Gastr & Pancreat Surg, Canc Ctr, Guangzhou, Peoples R ChinaSun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Canc Ctr, Guangzhou 510060, Peoples R China
Zhang, Miaoquan
Ding, Chao
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h-index: 0
机构:
Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Canc Ctr, Guangzhou 510060, Peoples R China
Sun Yat Sen Univ, Dept Gastr & Pancreat Surg, Canc Ctr, Guangzhou, Peoples R ChinaSun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Canc Ctr, Guangzhou 510060, Peoples R China
Ding, Chao
Xu, Lin
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机构:
Sun Yat Sen Univ, Sch Publ Hlth Shenzhen, Guangzhou 510006, Guangdong, Peoples R China
Guangdong Prov Key Lab Food Nutr & Hlth, Guangzhou 510080, Guangdong, Peoples R China
Guangdong Prov Engn Lab Nutr Translat, Guangzhou 510080, Guangdong, Peoples R ChinaSun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Canc Ctr, Guangzhou 510060, Peoples R China
Xu, Lin
Feng, Shoucheng
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机构:
Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Canc Ctr, Guangzhou 510060, Peoples R China
Sun Yat Sen Univ, Dept Gastr & Pancreat Surg, Canc Ctr, Guangzhou, Peoples R ChinaSun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Canc Ctr, Guangzhou 510060, Peoples R China
Feng, Shoucheng
Ling, Yudong
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机构:
Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Canc Ctr, Guangzhou 510060, Peoples R China
Sun Yat Sen Univ, Dept Gastr & Pancreat Surg, Canc Ctr, Guangzhou, Peoples R ChinaSun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Canc Ctr, Guangzhou 510060, Peoples R China
Ling, Yudong
Guo, Jianrong
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机构:
Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Canc Ctr, Guangzhou 510060, Peoples R China
Sun Yat Sen Univ, Dept Gastr & Pancreat Surg, Canc Ctr, Guangzhou, Peoples R ChinaSun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Canc Ctr, Guangzhou 510060, Peoples R China
Guo, Jianrong
Liang, Yao
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机构:
Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Canc Ctr, Guangzhou 510060, Peoples R China
Sun Yat Sen Univ, Dept Gastr & Pancreat Surg, Canc Ctr, Guangzhou, Peoples R ChinaSun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Canc Ctr, Guangzhou 510060, Peoples R China
Liang, Yao
Zhou, Zhiwei
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机构:
Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Canc Ctr, Guangzhou 510060, Peoples R China
Sun Yat Sen Univ, Dept Gastr & Pancreat Surg, Canc Ctr, Guangzhou, Peoples R ChinaSun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Canc Ctr, Guangzhou 510060, Peoples R China
Zhou, Zhiwei
Chen, Yingbo
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h-index: 0
机构:
Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Canc Ctr, Guangzhou 510060, Peoples R China
Sun Yat Sen Univ, Dept Gastr & Pancreat Surg, Canc Ctr, Guangzhou, Peoples R ChinaSun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Canc Ctr, Guangzhou 510060, Peoples R China
Chen, Yingbo
Qiu, Haibo
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h-index: 0
机构:
Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Canc Ctr, Guangzhou 510060, Peoples R China
Sun Yat Sen Univ, Dept Gastr & Pancreat Surg, Canc Ctr, Guangzhou, Peoples R ChinaSun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Canc Ctr, Guangzhou 510060, Peoples R China
机构:
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastrointestinal Surgery, Peking University Cancer Hospital & InstituteKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastrointestinal Surgery, Peking University Cancer Hospital & Institute
Zhixue Zheng
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Yinan Zhang
Lianhai Zhang
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Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastrointestinal Surgery, Peking University Cancer Hospital & InstituteKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastrointestinal Surgery, Peking University Cancer Hospital & Institute
Lianhai Zhang
Ziyu Li
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Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastrointestinal Surgery, Peking University Cancer Hospital & InstituteKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastrointestinal Surgery, Peking University Cancer Hospital & Institute
Ziyu Li
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Aiwen Wu
Xiaojiang Wu
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机构:
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastrointestinal Surgery, Peking University Cancer Hospital & InstituteKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastrointestinal Surgery, Peking University Cancer Hospital & Institute
Xiaojiang Wu
Yiqiang Liu
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机构:
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Pathology, Peking University Cancer Hospital & InstituteKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastrointestinal Surgery, Peking University Cancer Hospital & Institute
Yiqiang Liu
Zhaode Bu
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机构:
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastrointestinal Surgery, Peking University Cancer Hospital & InstituteKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastrointestinal Surgery, Peking University Cancer Hospital & Institute
Zhaode Bu
Jiafu Ji
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Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastrointestinal Surgery, Peking University Cancer Hospital & InstituteKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastrointestinal Surgery, Peking University Cancer Hospital & Institute
机构:
First Peoples Hosp Shuangliu Dist, Dept Gen Surg, Chengdu, Peoples R ChinaFirst Peoples Hosp Shuangliu Dist, Dept Gen Surg, Chengdu, Peoples R China
Zhang, Yajun
Yin, Tiansheng
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First Peoples Hosp Shuangliu Dist, Dept Gen Surg, Chengdu, Peoples R ChinaFirst Peoples Hosp Shuangliu Dist, Dept Gen Surg, Chengdu, Peoples R China
Yin, Tiansheng
Liu, Yang
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First Peoples Hosp Shuangliu Dist, Dept Gen Surg, Chengdu, Peoples R ChinaFirst Peoples Hosp Shuangliu Dist, Dept Gen Surg, Chengdu, Peoples R China
Liu, Yang
Xiao, Jiajun
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First Peoples Hosp Shuangliu Dist, Dept Gen Surg, Chengdu, Peoples R ChinaFirst Peoples Hosp Shuangliu Dist, Dept Gen Surg, Chengdu, Peoples R China
机构:
Yonsei Univ, Grad Sch Med, Dept Med, Seoul, South Korea
Natl Canc Ctr, Res Inst & Hosp, Gastr Canc Branch, Goyang, Gyeonggi Do, South KoreaYonsei Univ, Grad Sch Med, Dept Med, Seoul, South Korea
Eom, Bang Wool
Joo, Jungnam
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机构:
Natl Canc Ctr, Res Inst Natl Canc Control & Evaluat, Canc Biostat Branch, Goyang, Gyeonggi Do, South KoreaYonsei Univ, Grad Sch Med, Dept Med, Seoul, South Korea
Joo, Jungnam
Park, Boram
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h-index: 0
机构:
Natl Canc Ctr, Res Inst Natl Canc Control & Evaluat, Canc Biostat Branch, Goyang, Gyeonggi Do, South KoreaYonsei Univ, Grad Sch Med, Dept Med, Seoul, South Korea
Park, Boram
Jo, Min Jung
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h-index: 0
机构:
Natl Canc Ctr, Res Inst & Hosp, Gastr Canc Branch, Goyang, Gyeonggi Do, South KoreaYonsei Univ, Grad Sch Med, Dept Med, Seoul, South Korea
Jo, Min Jung
Choi, Seung Ho
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Yonsei Univ, Grad Sch Med, Dept Med, Seoul, South KoreaYonsei Univ, Grad Sch Med, Dept Med, Seoul, South Korea
Choi, Seung Ho
Cho, Soo-Jeong
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h-index: 0
机构:
Natl Canc Ctr, Res Inst & Hosp, Gastr Canc Branch, Goyang, Gyeonggi Do, South KoreaYonsei Univ, Grad Sch Med, Dept Med, Seoul, South Korea
Cho, Soo-Jeong
Ryu, Keun Won
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h-index: 0
机构:
Natl Canc Ctr, Res Inst & Hosp, Gastr Canc Branch, Goyang, Gyeonggi Do, South KoreaYonsei Univ, Grad Sch Med, Dept Med, Seoul, South Korea
Ryu, Keun Won
Kim, Young-Woo
论文数: 0引用数: 0
h-index: 0
机构:
Natl Canc Ctr, Res Inst & Hosp, Gastr Canc Branch, Goyang, Gyeonggi Do, South KoreaYonsei Univ, Grad Sch Med, Dept Med, Seoul, South Korea
Kim, Young-Woo
Kook, Myeong-Cherl
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Natl Canc Ctr, Res Inst & Hosp, Gastr Canc Branch, Goyang, Gyeonggi Do, South KoreaYonsei Univ, Grad Sch Med, Dept Med, Seoul, South Korea