Exploring the Intricacies of Neurogenic Niches: Unraveling the Anatomy and Neural Microenvironments

被引:2
|
作者
Sanchez-Gomar, Ismael [1 ]
Geribaldi-Doldan, Noelia [2 ]
Santos-Rosendo, Celeste [3 ]
Sanguino-Caneva, Ciro [4 ]
Carrillo-Chapman, Carlos [4 ]
Fiorillo-Moreno, Ornella [5 ,6 ]
Camacho, Jose Luis Villareal [7 ]
Quiroz, Elkin Navarro [8 ,9 ]
Verastegui, Cristina [2 ]
机构
[1] Univ Cadiz, Fac Med, Dept Biomed Biotecnol & Salud Publ, Area Fisiol, Cadiz 11003, Spain
[2] Univ Cadiz, Fac Med, Dept Anat & Embriol Humana, Cadiz 11003, Spain
[3] Univ Cadiz, Dept Biol, Cadiz 11519, Spain
[4] Univ Simon Bolivar, Fac Ciencias Salud, Programa Especializac Neurol, Barranquilla 080001, Colombia
[5] Clin Iberoamer, Barranquilla 080001, Colombia
[6] Clin Carmen, Barranquilla 080001, Colombia
[7] Univ Libre, Fac Ciencias Salud, Programa Med, Barranquilla 081007, Colombia
[8] Univ Simon Bolivar, Fac Ciencias Bas & Biomed, Ctr Invest Ciencias Vida, Barranquilla 080001, Colombia
[9] Fdn Univ San Martin, Fac Ciencias Salud, Programa Med, Barranquilla 080001, Colombia
关键词
anatomy; nervous system; neurogenic niches; neural stem cells; adult neurogenesis; ADULT HIPPOCAMPAL NEUROGENESIS; CENTRAL-NERVOUS-SYSTEM; STEM-CELL QUIESCENCE; HYPOTHALAMIC NEUROGENESIS; SUBVENTRICULAR ZONE; PROGENITOR CELLS; HUMAN BRAIN; SUBSTANTIA-NIGRA; OLFACTORY-BULB; HUMAN STRIATUM;
D O I
10.3390/biom14030335
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Neurogenesis is the process of forming new neurons from neural stem cells (NSCs). In adults, this process takes place in specific areas of the brain, known as neurogenic niches. These regions have unique anatomical features that have been studied in animal models and in the human brain; however, there are differences between these models that need to be addressed. The most studied areas are the subventricular zone, the lateral and latero-dorsal walls of the lateral ventricles, and the dentate gyrus of the hippocampus (Hp), which are known as the canonical areas. Other, less-studied niches, such as the hypothalamus, the cerebellum, and the amygdala, are known as non-canonical areas. Anatomy occupies a relevant place in adult neurogenesis, in which the tissue architecture and cellular location are necessities for the interaction and release of diverse molecules that allow this phenomenon. The cell arrangement within the niche and the location of the niche itself are of particular relevance to the state in which the NSCs are found. Consequently, the majority of previous discoveries have been related to pathology. While many studies are based on animal models, discoveries related to neurogenesis in humans have also been made; however, in this case, opinions vary, leading to extensive controversy in recent years. In this review, we address the anatomical characteristics of the different brain regions to better understand their relationships within neurogenesis.
引用
收藏
页数:25
相关论文
共 21 条
  • [1] Activation of neural precursors in the adult neurogenic niches
    Vukovic, Jana
    Blackmore, Daniel G.
    Jhaveri, Dhanisha
    Bartlett, Perry F.
    NEUROCHEMISTRY INTERNATIONAL, 2011, 59 (03) : 341 - 346
  • [2] Adult neural stem cells, neurogenic niches, and cellular therapy
    Philippe Taupin
    Stem Cell Reviews, 2006, 2 : 213 - 219
  • [3] Adult neural stem cells, neurogenic niches, and cellular therapy
    Taupin, Philippe
    STEM CELL REVIEWS, 2006, 2 (03): : 213 - 219
  • [4] Osteogenic and Neurogenic Stem Cells in Their Own Place: Unraveling Differences and Similarities Between Niches
    Lattanzi, Wanda
    Parolisi, Roberta
    Barba, Marta
    Bonfanti, Luca
    FRONTIERS IN CELLULAR NEUROSCIENCE, 2015, 9
  • [5] Are neural crest stem cells the missing link between hematopoietic and neurogenic niches?
    Coste, Cecile
    Neirinckx, Virginie
    Gothot, Andre
    Wislet, Sabine
    Rogister, Bernard
    FRONTIERS IN CELLULAR NEUROSCIENCE, 2015, 9
  • [6] BASP1 labels neural stem cells in the neurogenic niches of mammalian brain
    Manganas, Louis N.
    Dura, Irene
    Osenberg, Sivan
    Semerci, Faith
    Tosun, Mehmet
    Mishra, Rachana
    Parkitny, Luke
    Encinas, Juan M.
    Maletic-Savatic, Mirjana
    SCIENTIFIC REPORTS, 2021, 11 (01)
  • [7] Intermediate progenitors support migration of neural stem cells into dentate gyrus outer neurogenic niches
    Nelson, Branden R.
    Hodge, Rebecca D.
    Daza, Ray A. M.
    Tripathi, Prem Prakash
    Arnold, Sebastian J.
    Millen, Kathleen J.
    Hevner, Robert F.
    ELIFE, 2020, 9
  • [8] Amyotrophic lateral sclerosis modifies progenitor neural proliferation in adult classic neurogenic brain niches
    Galan, Lucia
    Gomez-Pinedo, Ulises
    Guerrero, Antonio
    Manuel Garcia-Verdugo, Jose
    Matias-Guiu, Jorge
    BMC NEUROLOGY, 2017, 17
  • [9] Amyotrophic lateral sclerosis modifies progenitor neural proliferation in adult classic neurogenic brain niches
    Lucía Galán
    Ulises Gómez-Pinedo
    Antonio Guerrero
    Jose Manuel García-Verdugo
    Jorge Matías-Guiu
    BMC Neurology, 17
  • [10] Unraveling the stride: exploring the influence of neurogenic orthostatic hypotension on gait and balance in Parkinson's disease
    Imbalzano, Gabriele
    Ledda, Claudia
    Tangari, Marta Maria
    Artusi, Carlo Alberto
    Montanaro, Elisa
    Rizzone, Mario Giorgio
    Zibetti, Maurizio
    Lopiano, Leonardo
    Romagnolo, Alberto
    CLINICAL AUTONOMIC RESEARCH, 2024, 34 (06) : 593 - 601