Evaluation of taurine and carnitine concentrations in whole blood, plasma, skeletal muscle and cardiac muscle in dogs

被引:4
|
作者
Mccauley, Sydney R. [1 ]
Clark, Stephanie D. [1 ]
Leach, Stacey B. [2 ]
Quest, Bradley W. [1 ]
Streeter, Renee M. [1 ,3 ]
机构
[1] BSM Partners, Rogers, AR 72758 USA
[2] Univ Missouri, Coll Vet Med, Columbia, MO USA
[3] BSM Partners, Nutr Practice, 83 W Champ Blvd, Rogers, AR 72758 USA
关键词
cardiac; carnitine; dilated cardiomyopathy; muscle; taurine; DILATED CARDIOMYOPATHY; HEALTHY DOGS; DEFICIENCY; METABOLISM; PREVALENCE; CYSTEINE;
D O I
10.1111/jpn.13946
中图分类号
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号
0905 ;
摘要
Little is known about how plasma and whole blood taurine and plasma carnitine correlate to concentrations in skeletal and cardiac muscle and the effects of diet in dogs. The purpose of this study was to evaluate the correlation among plasma, skeletal and cardiac muscle carnitine and taurine and whole blood taurine and determine the effect of diet. The study protocol was approved by the Pet Food Solutions Institutional Animal Care and Use Committee. Thirty-three mixed-breed hounds and 32 beagles were evaluated at Day 0 then removed from their baseline diet and randomized to a test diet: high animal protein, grain-inclusive (HA-GI), low animal protein, grain-free (LA-GF), low animal protein, grain-inclusive (LA-GI), or high animal protein, grain-free (HA-GF). Blood was drawn every 30 days and endomyocardial (mixed breeds only) and skeletal muscle biopsies were collected at Days 0 and 180. The correlations between plasma and whole blood taurine, or plasma carnitine and skeletal and cardiac muscle concentrations were weak (p < 0.01-0.05). Mixed-breed hounds had increased (p = 0.029) whole blood taurine compared to beagles. Plasma taurine was lower with diet HA-GF, (p = 0.009) however, all diets had increased taurine from Day 0 and were, on average within the laboratory reference range. Dogs fed the HA-GI diet had increased cardiac muscle carnitine esters (p = 0.014). Increased carnitine esters were also appreciated in cardiac muscle in all diets from Day 0 to 180 (p = 0.0001). On Day 180 mixed-breed hounds had increased skeletal total carnitine (p < 0.001) compared to all time points and breeds. This study observed no correlation between plasma, whole blood, skeletal and cardiac muscle taurine concentrations but noted some effects between time, breed and diet.
引用
收藏
页码:999 / 1015
页数:17
相关论文
共 50 条
  • [1] Kinetics of taurine depletion and repletion in plasma, serum, whole blood and skeletal muscle in cats
    L. Pacioretty
    M. A. Hickman
    J. G. Morris
    Q. R. Rogers
    Amino Acids, 2001, 21 : 417 - 427
  • [2] Kinetics of taurine depletion and repletion in plasma, serum, whole blood and skeletal muscle in cats
    Pacioretty, L
    Hickman, MA
    Morris, JG
    Rogers, QR
    AMINO ACIDS, 2001, 21 (04) : 417 - 427
  • [3] Effects of dietary fat and L-carnitine on plasma and whole blood taurine concentrations and cardiac function in healthy dogs fed protein-restricted diets
    Sanderson, SL
    Gross, KL
    Ogburn, PN
    Calvert, C
    Jacobs, G
    Lowry, SR
    Bird, KA
    Koehler, LA
    Swanson, LL
    AMERICAN JOURNAL OF VETERINARY RESEARCH, 2001, 62 (10) : 1616 - 1623
  • [4] CARNITINE AND ACETYLCARNITINE IN SKELETAL AND CARDIAC-MUSCLE
    CIMAN, M
    VALERI, VC
    SILIPRANDI, N
    INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH, 1978, 48 (02) : 177 - 181
  • [5] DIETARY CARNITINE INTAKE RELATED TO SKELETAL-MUSCLE AND PLASMA CARNITINE CONCENTRATIONS IN ADULT MEN AND WOMEN
    LENNON, DLF
    SHRAGO, ER
    MADDEN, M
    NAGLE, FJ
    HANSON, P
    AMERICAN JOURNAL OF CLINICAL NUTRITION, 1986, 43 (02): : 234 - 238
  • [6] Skeletal muscle and plasma concentrations of cefazolin
    Jutte, P. C.
    Ploegmakers, J. J. W.
    Bulstra, S. K.
    BRITISH JOURNAL OF ANAESTHESIA, 2016, 117 (01) : 3 - +
  • [7] Skeletal muscle and plasma concentrations of cefazolin during cardiac surgery in infants
    Himebauch, Adam S.
    Nicolson, Susan C.
    Sisko, Martha
    Moorthy, Ganesh
    Fuller, Stephanie
    Gaynor, J. William
    Zuppa, Athena F.
    Fox, Elizabeth
    Kilbaugh, Todd J.
    JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 2014, 148 (06): : 2634 - 2641
  • [8] DIETARY CARNITINE SHOWS DIVERGENT REPLETION OF SKELETAL-MUSCLE CARNITINE AND CARDIAC-MUSCLE CARNITINE IN NEONATAL PIGLETS
    BORUM, PR
    SULLIVAN, MP
    CLINICAL RESEARCH, 1988, 36 (03): : A755 - A755
  • [9] DIETARY CARNITINE SHOWS DIVERGENT REPLETION OF SKELETAL-MUSCLE CARNITINE AND CARDIAC-MUSCLE CARNITINE IN NEONATAL PIGLETS
    BORUM, PR
    SULLIVAN, MP
    AMERICAN JOURNAL OF CLINICAL NUTRITION, 1988, 47 (04): : 778 - 778
  • [10] Platelet taurine concentration can be predicted from whole blood taurine concentrations in dogs
    Torres, CL
    Walker, NJ
    Rogers, QR
    Tablin, F
    JOURNAL OF NUTRITION, 2006, 136 (07): : 2055S - 2057S