Evaluation of a Live-Attenuated Human Parainfluenza Virus Type 2 Vaccine in Adults and Children

被引：1
|
作者：
Karron, Ruth A. [1 ,4 ]
Herbert, Kristi [1 ]
Wanionek, Kimberli [1 ]
Schmidt, Alexander C. [2 ,3 ]
Schaap-Nutt, Anne [2 ]
Collins, Peter L. [2 ]
Buchholz, Ursula J. [2 ]
机构：
[1] Johns Hopkins Bloomberg Sch Publ Hlth, Ctr Immunizat Res, Dept Int Hlth, Baltimore, MD USA
[2] NIAID, RNA Viruses Sect, Lab Infect Dis, NIH, Bethesda, MD USA
[3] Bill & Melinda Gates Med Res Inst, Cambridge, MA USA
[4] Ctr Immunizat Res, 624 N Broadway, Baltimore, MD 21205 USA
来源：
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY | 2023年 / 12卷 / 03期
关键词：
live-attenuated; parainfluenza; vaccine; MUTATIONS; CANDIDATES; SAFETY;
D O I：
10.1093/jpids/piac137
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
We conducted a phase I clinical trial of the live-attenuated recombinant human parainfluenza virus type 2 (HPIV2) vaccine candidate rHPIV2-15C/948L/ increment 1724 sequentially in adults, HPIV2-seropositive children, and HPIV2-seronegative children, the target population for vaccination. rHPIV2-15C/948L/ increment 1724 was appropriately restricted in replication in adults and HPIV2-seropositive children but was overattenuated for HPIV2-seronegative children.
引用
收藏
页码：173 / 176
页数：4
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