Synthesis and Aminomethylation of A-Azepane-Fused Uvaol and Betulin Derivatives

被引：1
|
作者：
Petrova, A. V. [1 ]
机构：
[1] Russian Acad Sci, Ufa Fed Res Ctr, Ufa Inst Chem, Ufa 450054, Russia
来源：
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 59卷 / 01期
关键词：
triterpenoids; azepanobetulin; azepanouvaol; alkylation; Mannich reaction; HYDROXYPROPARGYLAMINES; CYTOTOXICITY;
D O I：
10.1134/S1070428023010232
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Stepwise conjugation of biologically active A-azepanobetulin and A-azepanouvaol with succinic anhydride and propargylamine, followed by copper-catalyzed Mannich reaction, afforded new hybrid com-pounds containing an N-methylpiperazine fragment with an average yield of 73%. The product structure was determined by NMR spectroscopy.
引用
收藏
页码：202 / 206
页数：5
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