New Schiff Bases with Thiophene Ring: Synthesis, Biological Activities, and Molecular Docking Study

被引：5
|
作者：
Celik, F. [1 ]
Bektas, K. I. [2 ]
Guler, H. I. [2 ]
Direkel, S. [3 ]
Unver, Y. [1 ]
机构：
[1] Karadeniz Tech Univ, Fac Sci, Dept Chem, TR-61080 Trabzon, Turkiye
[2] Karadeniz Tech Univ, Fac Sci, Dept Mol Biol & Genet, TR-61080 Trabzon, Turkiye
[3] Giresun Univ, Fac Med, Dept Med Microbiol, TR-28100 Giresun, Turkiye
来源：
RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2023年 / 93卷 / 02期
关键词：
Schiff bases; thiophene; leishmanicidal activity; antimicrobial activity; molecular docking study; DERIVATIVES; ANTIOXIDANT; DFT;
D O I：
10.1134/S107036322302024X
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In this study, the synthesis of Schiff bases containing substituted thiophene was carried out. The compounds were characterized by Fourier transform infrared (FTIR), H-1 and C-13 NMR spectroscopy methods. In the study, it was aimed to determine in vitro leishmanicidal activities of five different newly synthesized compounds against standard L. infantum promastigotes by microdilution method. In silico analysis was used to examine the probable interactions between the synthesized compound and the target proteins.
引用
收藏
页码：409 / 417
页数：9
相关论文
共 50 条
  • [1] New Schiff Bases with Thiophene Ring: Synthesis, Biological Activities, and Molecular Docking Study
    F. Çelik
    K. İ. Bektaş
    H. İ. Güler
    Ş. Direkel
    Y. Ünver
    Russian Journal of General Chemistry, 2023, 93 : 409 - 417
  • [2] Synthesis and Urease Inhibition Activities of Some New Schiff Bases Benzimidazoles Containing Thiophene Ring
    Akyuez, Guelay
    RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY, 2024, 50 (03) : 974 - 981
  • [3] New Chalcone Derivatives with Schiff Base-Thiophene: Synthesis, Biological Activity, and Molecular Docking Studies
    Unver, Y.
    Tuluk, M.
    Kahriman, N.
    Emirik, M.
    Bektas, E.
    Direkel, S.
    RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2019, 89 (04) : 794 - 799
  • [4] New Chalcone Derivatives with Schiff Base-Thiophene: Synthesis, Biological Activity, and Molecular Docking Studies
    Y. Ünver
    M. Tuluk
    N. Kahriman
    M. Emirik
    E. Bektaş
    Ş. Direkel
    Russian Journal of General Chemistry, 2019, 89 : 794 - 799
  • [5] Molecular docking study, synthesis and biological evaluation of Schiff bases as Hsp90 inhibitors
    Gupta, Sayan Dutta
    Snigdha, D.
    Mazaira, Gisela I.
    Galigniana, Mario D.
    Subrahmanyam, C. V. S.
    Gowrishankar, N. L.
    Raghavendra, N. M.
    BIOMEDICINE & PHARMACOTHERAPY, 2014, 68 (03) : 369 - 376
  • [6] Sulfamethoxazole-derived Schiff bases: Synthesis, characterization, biological activities, molecular docking, DFT, and ADME studies
    Wajid, Muhammad
    Uzair, Muhammad
    Muhammad, Gulzar
    Siddique, Farhan
    Bashir, Maryam
    Nadeem, Sumaira
    Ashraf, Adnan
    Assad, Nasir
    Mushtaq, Aamir
    Rafay, Muhammad Zohaib
    Aqdas, Amna
    Ahmad, Sajjad
    Alasmari, Abdullah F.
    JOURNAL OF MOLECULAR STRUCTURE, 2024, 1312
  • [7] Synthesis of new arylhydrazide bearing Schiff bases/thiazolidinone: α-Amylase, urease activities and their molecular docking studies
    Rahim, Fazal
    Taha, Muhammad
    Ullah, Hayat
    Wadood, Abdul
    Selvaraj, Manikandan
    Rab, Abdur
    Sajid, Muhammad
    Shah, Syed Adnan Ali
    Uddin, Nizam
    Gollapalli, Mohammed
    BIOORGANIC CHEMISTRY, 2019, 91
  • [8] Synthesis, antibacterial activities and molecular docking studies of peptide and Schiff bases as targeted antibiotics
    Cheng, Kui
    Zheng, Qing-Zhong
    Qian, Yong
    Shi, Lei
    Zhao, Jing
    Zhu, Hai-Liang
    BIOORGANIC & MEDICINAL CHEMISTRY, 2009, 17 (23) : 7861 - 7871
  • [9] Biological Activities, DFT and Molecular Docking Studies of Novel Schiff Bases Derived from Sulfamethoxypyridazine
    Wajid, Muhammad
    Uzair, Muhammad
    Muhammad, Gulzar
    Siddique, Farhan
    Ashraf, Adnan
    Ahmad, Sajjad
    Alasmari, Abdullah F.
    CHEMISTRYSELECT, 2024, 9 (15):
  • [10] Synthesis, structure, biological/chemosensor evaluation and molecular docking studies of aminobenzothiazole Schiff bases
    Suyambulingam, Jone Kirubavathy
    Karvembu, Ramasamy
    Bhuvanesh, Nattamai S. P.
    Enoch, Israel V. Muthu Vijayan
    Selvakumar, Paulraj Mosae
    Premnath, Dhanaraj
    Subramanian, Chitra
    Mayakrishnan, Prabakaran
    Kim, Seung-Hyun
    Chung, Ill-Min
    JOURNAL OF ADHESION SCIENCE AND TECHNOLOGY, 2020, 34 (23) : 2590 - 2612
12345