Doxycycline Prophylaxis for Skin and Soft Tissue Infections in Naval Special Warfare Trainees, United States

被引：0

作者：

Spiro, Jeffrey ^{[1
,6
]}

Wisniewski, Piotr ^{[1
,2
]}

Schwartz, Julia ^{[3
]}

Smith, Alfred G. ^{[4
]}

Burger, Sara ^{[3
]}

Tilley, Drake H. ^{[1
]}

Maves, Ryan C. ^{[1
,5
]}

机构：

[1] Naval Med Ctr, San Diego, CA 92134 USA

[2] Naval Hlth Res Ctr, San Diego, CA USA

[3] Naval Special Warfare Ctr, Coronado, CA USA

[4] Naval Med Ctr, Portsmouth, VA USA

[5] Wake Forest Univ, Sch Med, Winston salem, NC USA

[6] Naval Med Ctr, Div Infect Dis, 34800 Bob Wilson Dr, San Diego, CA 92134 USA

来源：

EMERGING INFECTIOUS DISEASES | 2024年 / 30卷 / 01期

关键词：

PREOPERATIVE DOXYCYCLINE; MALARIA CHEMOPROPHYLAXIS; PROPIONIBACTERIUM-ACNES; MILITARY; TETRACYCLINES; PREVENTION; SHOULDER; PATTERNS; EFFICACY; SEX;

D O I：

10.3201/eid3001.230890

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In 2015, several severe cases of skin and soft tissue infection (SSTI) among US Naval Special Warfare trainees prompted the introduction of doxycycline prophylaxis during the highest-risk portion of training, Hell Week. We performed a retrospective analysis of the effect of this intervention on SSTI incidence and resulting hospital admissions during 2013-2020. In total, 3,371 trainees underwent Hell Week training during the study period; 284 SSTIs were diagnosed overall, 29 of which led to hospitalization. After doxycycline prophylaxis was introduced, admission rates for SSTI decreased from 1.37 to 0.64 admissions/100 trainees (p = 0.036). Overall SSTI rates remained stable at 7.42 to 8.86 SSTIs/100 trainees (p = 0.185). Hospitalization rates per diagnosed SSTI decreased from 18.4% to 7.2% (p = 0.009). Average length of hospitalization decreased from 9.01 days to 4.33 days (p = 0.034). Doxycycline prophylaxis was associated with decreased frequency and severity of hospitalization for SSTIs among this population.

引用

页码：89 / 95

页数：7

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