Telomere length is not a useful tool for chronological age estimation in animals

Telomeres are short repetitive DNA sequences capping the ends of chromosomes. Telomere shortening occurs during cell division and may be accelerated by oxidative damage or ameliorated by telomere maintenance mechanisms. Consequently, telomere length changes with age, which was recently confirmed in a large meta-analysis across vertebrates. However, based on the correlation between telomere length and age, it was concluded that telomere length can be used as a tool for chronological age estimation in animals. Correlation should not be confused with predictability, and the current data and studies suggest that telomeres cannot be used to reliably predict individual chronological age. There are biological reasons for why there is large individual variation in telomere dynamics, which is mainly due to high susceptibility to a wide range of environmental, but also genetic factors, rendering telomeres unfeasible as a tool for age estimation. The use of telomeres for chronological age estimation is largely a misguided effort, but its occasional reappearance in the literature raises concerns that it will mislead resources in wildlife conservation. Telomere dynamics are influenced by environmental and genetic factors through changes in cell replication, oxidative stress, and telomere maintenance, which cause heterogeneity in telomere lengths at multiple spatiotemporal scales. Although telomere dynamics correlate with age, their ability to predict chronological age is poor. Modified from wildpixel (iStock) and Wikimedia Commons.image