In academia, saying "yes" to opportunities and "no" to distractions is crucial for effective decision-making. Here, we emphasize the importance of carefully considering commitments and courageously declining those that may lead to overextension. We highlight that discernment is vital, particularly for junior faculty/scientists and those with marginalized identities, as overcommitment can hinder career advancement. The "Fame, Fortune, and Fun test" offers a practical heuristic for evaluating opportunities, enabling academics to make informed choices. Saying "no" effectively involves preserving personal and professional integrity by declining tasks that do not align with one's abilities or interests. However, challenges in saying "no" are multifaceted, including fear of missing career advancements, pressures to please superiors or peers, and perceived negative consequences. This decision can be even more complex for individuals with minoritized identities, as additional expectations and responsibilities may arise due to implicit biases. The article provides a scheme for academics when deciding whether to accept or decline opportunities. The "Fame, Fortune, and Fun test" is a simplified scheme based on the Japanese concept of Ikigai, which comes from two words that mean life's purpose. The concept allows an individual to determine their reason for being and aim to align their time spent with as many components that satisfy the following four categories: what one loves, what one is good at, what one can be paid for, and what the world needs. The more overlap, the more alignment with Ikigai, and the more compelling reason to say yes. Once one has determined that they can say no, effectively saying "no" involves clear and direct communication, offering alternatives, expressing gratitude, and considering a "not now" approach if unable to commit immediately. To promote inclusivity, we suggest recommending individuals from diverse backgrounds for opportunities. By amplifying underrepresented voices, we can foster a healthier academic environment. Saying "no" empowers academics to prioritize meaningful contributions and maintain work-life balance. Embracing the power of "no" is essential for maintaining integrity and well-being in academia. Junior faculty/scientists and individuals with marginalized identities may face additional challenges in their decision-making. By carefully evaluating commitments and effectively declining non-aligning opportunities, academics can focus on what truly matters, fostering a supportive and thriving academic environment.
