Epigenetic regulation of early human embryo development

被引：13
|
作者：
Wilkinson, Amy L. [1 ]
Zorzan, Irene [1 ]
Rugg-Gunn, Peter J. [1 ,2 ,3 ]
机构：
[1] Babraham Inst, Epigenet Programme, Cambridge, England
[2] Univ Cambridge, Ctr Trophoblast Res, Cambridge, England
[3] Wellcome MRC Cambridge Stem Cell Inst, Cambridge, England
来源：
CELL STEM CELL | 2023年 / 30卷 / 12期
基金：
英国生物技术与生命科学研究理事会; 英国惠康基金;
关键词：
HUMAN PREIMPLANTATION EMBRYOS; X-CHROMOSOME INACTIVATION; DNA METHYLATION; MOUSE OOCYTES; CHROMATIN ARCHITECTURE; TRANSPOSABLE ELEMENTS; SELF-ORGANIZATION; PLURIPOTENT; CELLS; BLASTOCYST;
D O I：
10.1016/j.stem.2023.09.010
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Studies of mammalian development have advanced our understanding of the genetic, epigenetic, and cellular processes that orchestrate embryogenesis and have uncovered new insights into the unique aspects of human embryogenesis. Recent studies have now produced the first epigenetic maps of early human embryogenesis, stimulating new ideas about epigenetic reprogramming, cell fate control, and the potential mechanisms underpinning developmental plasticity in human embryos. In this review, we discuss these new insights into the epigenetic regulation of early human development and the importance of these processes for safeguarding development. We also highlight unanswered questions and key challenges that remain to be addressed.
引用
收藏
页码：1569 / 1584
页数：16
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