Evaluation of Psychopathologies and Health-Related Quality of Life in Patients With Macular Amyloidosis

Macular amyloidosis (MA) is a skin condition with predominance in young women. We aimed to evaluate quality of life (QoL) and psychopathologies in these patients. In this cross-sectional study, patients with MA referring to the Imam Reza Hospital, Mashhad during 2018-2020, and their matched controls were included. Participants completed the 36-item short form survey (SF-36), the revised symptom checklist-90 (SCL-90-R), and the dermatology life quality index (DLQI). Overall, 40 women with a mean age of 36.80 +/- 10.19 years were studied. In the MA group, the SF-36 score was lower (P < 0.001), and the SCL-90-R score was higher (P < 0.001). The DLQI score was correlated with age (r = 0.447; P = 0.048) and pruritus severity (r = 0.776; P < 0.001), and was lower in patients with uncovered lesions (P = 0.005). MA was associated with impaired QoL, which was determined by pruritus severity and lesion location; these patients can benefit from psychiatric interventions in this regard. (c) 2023 AEDV. Published by Elsevier Espana, S.L.U. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).