BN-biphenyl nanosheet as a potential drug carrier for 5-Fluorouracil: A DFT investigation

被引：1
|
作者：
Saadh, Mohamed J. [1 ]
Rasheed, Yousry Sadoon [2 ]
Sdiq, Zhino Mohammed [3 ]
Chandra, Subhash [4 ]
Lateef, Sabbar Rashid [5 ]
Ghnim, Zahraa Sabah [6 ]
Al-Abdeen, Salah Hassan Zain [7 ]
Hawas, Majli Nema [8 ]
Elmasry, Yasser [9 ]
机构：
[1] Middle East Univ, Fac Pharm, Amman 11831, Jordan
[2] Univ Anbar, Coll Sci, Biol Dept, Ramadi, Iraq
[3] Sulaymaniyah Polytech Univ, Tech Inst, Pediat Dept, Sulaymaniyah, Iraq
[4] GLA Univ, Dept Elect Engn, Mathura 281406, India
[5] Imam Jaafar AL Sadiq Univ, Coll Med Lab Technol, Dept Med Lab Technol, Baghdad, Iraq
[6] Al Noor Univ Coll, Dept Pharm, Nineveh, Iraq
[7] AL Nisour Univ Coll, Dept Med Labs Technol, Baghdad, Iraq
[8] AL Nisour Univ Coll, Dept Med Labs Technol, Baghdad, Iraq
[9] King Khalid Univ, Fac Sci, Dept Phys, POB 9004, Abha, Saudi Arabia
来源：
INORGANIC CHEMISTRY COMMUNICATIONS | 2024年 / 160卷
关键词：
Drug delivery; 5-fluorouracil; Anti-cancer drug; BN-biphenyl nanosheet; BORON-NITRIDE; ELECTRONIC-STRUCTURE; GRAPHYNE; GRAPHDIYNE; DISPERSION; ENERGY; MODEL;
D O I：
10.1016/j.inoche.2023.111857
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Thus far, numerous pieces of research have been undertaken into developing new drug delivery systems. Within the current piece of research, the BN-biphenyl nanosheet (BN-bNS) was employed as a BN-analog of biphenyl. The DFT estimations were undertaken to explore the interaction between the anti-cancer drug 5-fluorouracil (5FU) and BN-bNS. Moreover, the results demonstrated the chemical reactivity of the complex of 5-FU/ BN-bNS, which demonstrated its suitability for 5-FU bonding with the adsorptive site. Moreover, for the better understanding of the complexes of 5-FU BN-bNS, we performed the noncovalent interaction analysis, and the interaction between 5-FU and BN-bNS was found to be strong. So, BN-bNS can be used a promising nanocarrier for 5FU for drug delivery purposes.
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页数：7
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