Impact of COVID-19 on Nonpulmonary Critical Illness Prevalence, Clinical Manifestations, Management, and Outcomes

Although SARS-CoV-2 infection most commonly causes respiratory symptoms and impairment, it can also cause nonpulmonary organ dysfunction, most commonly shock, AKI, and hypercoagulabil-ity. Neurologic, cardiac, and, to a lesser degree, liver injury may also occur from SARS-CoV-2. Management of extrapulmonary organ dysfunc-tion largely focuses on supportive care practices that are applicable regardless of the cause of or-gan injury. However, there is emerging evidence to support therapeutic anticoagulation in noncriti-cally ill patients to mitigate risk for VTE.