Associations of white blood cell and platelet counts with specific depressive symptom dimensions in patients with bipolar disorder: Analysis of data from the FACE-BD cohort

被引：8

作者：

Lengvenyte, Aiste ^{[1
,2
,3
,4
]}

Strumila, Robertas ^{[1
,2
,3
]}

Belzeaux, Raoul ^{[2
,4
,5
,6
]}

Aouizerate, Bruno ^{[4
,7
,8
]}

Dubertret, Caroline ^{[4
,9
,10
,11
]}

Haffen, Emmanuel ^{[4
,12
]}

Llorca, Pierre-Michel ^{[4
,13
,14
]}

Roux, Paul ^{[4
,15
]}

Polosan, Mircea ^{[4
,16
]}

Schwan, Raymund ^{[4
,17
]}

Walter, Michel ^{[4
,18
]}

D' Amato, Thierry ^{[4
,19
,20
]}

Januel, Dominique ^{[4
,21
]}

Leboyer, Marion ^{[4
,22
,23
]}

Bellivier, Frank ^{[4
,9
,24
,25
]}

Etain, Bruno ^{[4
,9
,24
,25
]}

Navickas, Alvydas ^{[3
]}

Olie, Emilie ^{[1
,2
,4
]}

Courtet, Philippe ^{[1
,2
,4
]}

机构：

[1] CHU Montpellier, Dept Emergency Psychiat & Acute Care, Lapeyronie Hosp, Montpellier, France

[2] Univ Montpellier, IGF, CNRS, INSERM, Montpellier, France

[3] Vilnius Univ, Inst Clin Med, Fac Med, Psychiat Clin, Vilnius, Lithuania

[4] Fdn FondaMental, Creteil, France

[5] AP HM, Pole Psychiat, Marseille, France

[6] Aix Marseille Univ, INT UMR7289, CNRS, Marseille, France

[7] Ctr Hosp Charles Perrens, Bordeaux, France

[8] Univ Bordeaux, Lab NutriNeuro UMR INRA 1286, Bordeaux, France

[9] Univ Paris Cite, Paris, France

[10] Hop Louis Mourier, Grp Hosp Univ AP HP Nord, AP HP, Serv Psychiat & Addictol,DMU ESPRIT, Colombes, France

[11] Univ Paris, Sorbonne Paris Cite, INSERM, Fac Med,UMR1266, Paris, France

[12] UBFC, CHU Besancon, Lab Neurosci, INSERM,UFC,Serv Psychiat Adulte,CIC 1431, Besancon, France

[13] Ctr Hosp & Univ, Dept Psychiat, Clermont Ferrand, France

[14] Univ Auvergne, EA 7280, Clermont Ferrand, France

[15] Univ Paris Saclay, Ctr Hosp Versailles, UVSQ, CESP UMR1018,DevPsy DisAP,Pole Psychiat & Sante M, F-78157 Le Chesnay, France

[16] Univ Grenoble Alpes, Grenoble Inst Neurosci, INSERM, CHU Grenoble Alpes,U1216, Grenoble, France

[17] Univ Lorraine, Ctr Psychotherap Nancy, INSERM, U1254, Nancy, France

[18] Hop Bohars, CHRU Brest, Serv Hosp Univ Psychiat Gen & Rehabil Psycho Soci, Brest, France

[19] Univ Lyon 1, Villeurbanne, France

[20] Lyon Neurosci Res Ctr, Psychiat Disorders Resistance Response Team, UMR5292, INSERM,U1028,CNRS, Lyon, France

[21] EPS Ville Evrard, Unite Rech Clin, F-93332 Neuilly Sur Marne, France

[22] Univ Paris Est Creteil, Translat NeuroPsychiat Lab, INSERM, IMRB,U955, Creteil, France

[23] Hop Univ Henri Mondor, AP HP, Dept Med Univ Psychiat & Addictol DMU IMPACT, Federat Hosp Univ Med Precis Psychiat FHU ADAPT, Creteil, France

[24] Hop Fernand Widal, Grp Hosp Univ AP HP Nord, AP HP, Dept Psychiat & Med Addictol,DMU Neurosci, Paris, France

[25] Univ Paris Cite, INSERM, UMR S 1144, Optimisat Therapeut Neuropsychopharmacol OTeN, Paris, France

来源：

BRAIN BEHAVIOR AND IMMUNITY | 2023年 / 108卷

关键词：

Inflammation; Blood cells; Depression; Bipolar disorder; Heterogeneity; OXIDATIVE STRESS; INFLAMMATION; SCHIZOPHRENIA; METAANALYSIS; LYMPHOCYTE; NEUTROPHIL; ACTIVATION; MECHANISMS; SEROTONIN; MONOCYTE;

D O I：

10.1016/j.bbi.2022.12.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Evidences suggest that inflammation is increased in a subgroup of patients with depression. Moreover, increased peripheral inflammatory markers (cells and proteins) are associated with some, but not all depressive symptoms. On the other hand, similar studies on bipolar disorders mainly focused on blood cytokines. Here, we analysed data from a large (N = 3440), well-characterized cohort of individuals with bipolar disorder using Kendall partial rank correlation, multivariate linear regression, and network analyses to determine whether peripheral blood cell counts are associated with depression severity, its symptoms, and dimensions. Based on the self-reported 16-Item Quick Inventory of Depressive Symptomatology questionnaire scores, we preselected symptom dimensions based

引用

页码：176 / 187

页数：12

共 4 条

[1] Associations between residual depressive symptoms, cognition, and functioning in patients with euthymic bipolar disorder: results from the FACE-BD cohort
Roux, Paul
Raust, Aurelie
Cannavo, Anne-Sophie
Aubin, Valerie
Aouizerate, Bruno
Azorin, Jean-Michel
Bellivier, Frank
Belzeaux, Raoul
Bougerol, Thierry
Cussac, Irena
Courtet, Philippe
Etain, Bruno
Gard, Sebastien
Job, Sophie
Kahn, Jean-Pierre
Leboyer, Marion
Olie, Emilie
Henry, Chantal
Passerieux, Christine
BRITISH JOURNAL OF PSYCHIATRY, 2017, 211 (06) : 381 - +
[2] Metabolic Syndrome in a French Cohort of Patients With Bipolar Disorder: Results From the FACE-BD Cohort
Godin, Ophelia
Etain, Bruno
Henry, Chantal
Bougerol, Thierry
Courtet, Philippe
Mayliss, Leroux
Passerieux, Christine
Azorin, Jean-Michel
Kahn, Jean-Pierre
Gard, Sebastien
Costagliola, Dominique
Leboyer, Marion
JOURNAL OF CLINICAL PSYCHIATRY, 2014, 75 (10) : 1078 - 1085
[3] Depressive residual symptoms are associated with lower adherence to medication in bipolar patients without substance use disorder: Results from the FACE-BD cohort
Belzeaux, Raoul
Correard, Nadia
Boyer, Laurent
Etain, Bruno
Loftus, Josephine
Bellivier, Frank
Bougerol, Thierry
Courtet, Philippe
Gard, Sebastien
Kahn, Jean-Pierre
Passerieux, Christine
Leboyer, Marion
Henry, Chantal
Azorin, Jean-Michel
JOURNAL OF AFFECTIVE DISORDERS, 2013, 151 (03) : 1009 - 1015
[4] Violent suicide attempt history in elderly patients with bipolar disorder: The role of sex, abdominal obesity, and verbal memory: Results from the FACE-BD cohort (FondaMental Advanced center of Expertise for Bipolar Disorders)
Lengvenyte, Aiste
Aouizerate, Bruno
Aubin, Valerie
Loftus, Josephine
Marlinge, Emeline
Belzeaux, Raoul
Dubertret, Caroline
Gard, Sebastien
Haffen, Emmanuel
Schwan, Raymund
Llorca, Pierre-Michel
Passerieux, Christine
Roux, Paul
Polosan, Mircea
Etain, Bruno
Leboyer, Marion
Courtet, Philippe
Olie, Emilie
JOURNAL OF AFFECTIVE DISORDERS, 2022, 296 : 265 - 276

← 1 →