The Roles and Targeting of Tumor-Associated Macrophages

被引：7
|
作者：
Li, Yuqian [1 ]
Wang, Ruoyao [1 ]
Gao, Qianqian [1 ]
机构：
[1] Shenzhen Bay Lab, Shenzhen 518132, Guangdong, Peoples R China
来源：
FRONTIERS IN BIOSCIENCE-LANDMARK | 2023年 / 28卷 / 09期
关键词：
tumor-associated macrophages; tumor microenvironment; macrophage roles; macrophage targeting; cancer therapy; CANCER STEM-CELL; PANCREATIC-CANCER; RESIDENT MACROPHAGES; IMMUNE EVASION; PROMOTE; POLARIZATION; BLOCKADE; INFLAMMATION; METASTASIS; GROWTH;
D O I：
10.31083/j.fbl2809207
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Tumor-associated macrophages (TAMs) are the most abundant infiltrating immune cells in the tumor microenvironment (TME) and play an important role in tumor progression. Clinically, the increase of TAMs infiltration is linked to poor prognosis of patients with various cancer types. Multiple studies have demonstrated that reducing or reprogramming TAMs can inhibit the occurrence or development of tumors. Therefore, TAMs have been identified as novel targets for the treatment of cancer therapy. In this review, the origin, polarization, roles, and targeting of TAMs in malignancies, are discussed.
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页数：10
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