Multi-Component Synthesis of Indole-Substituted Heterocycles- A Review

Considering the very important medicinal and biological properties of heterocycles incorporated indole skeleton, synthesis of these compounds is of great interest to medicinal and organic chemists, especially researchers who are involved in the synthesis of heterocycles. The present review focuses on the recent investigation in the synthesis of heterocycles with indole moiety using indole derivatives as reactant via multi-component reaction for the period of 2012-2022. Reports were categorized based on the type of indole substitution. The main aim of this review is to provide a summary of recently reported methods in the use of indole derivatives in multicomponent synthesis of heterocyclic compounds for organic and medicinal chemists.