Construction of Indole-Fused Seven- and Eight-Membered Azaheterocycles via a Tandem Pd/NBE-Catalyzed Decarbonylation and Dual C-H Activation Sequence

被引：6
|
作者：
Liu, Yu-Wen [1 ]
Wang, Meng-Meng [2 ]
Zhang, Yun-Qian [1 ]
Xu, Hui [1 ]
Dai, Hui-Xiong [1 ,2 ,3 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, State Key Lab Drug Res, Shanghai 201203, Peoples R China
[2] Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Jiangsu, Peoples R China
[3] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
来源：
ORGANIC LETTERS | 2023年 / 25卷 / 29期
基金：
中国国家自然科学基金;
关键词：
ARYL IODIDES; REGIOSELECTIVE SYNTHESIS; PALLADIUM; NORBORNENE; THIOESTERS; ROUTE; FUNCTIONALIZATION; ALKYLATION;
D O I：
10.1021/acs.orglett.3c01579
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Herein, we report the transformation of aromatic acidsto indole-fusedseven- and eight-membered azaheterocycles. Two C-C bonds areformed via the cleavage of one C-C bond and two C-Hbonds. The incorporation of indole moieties into bioactive pharmaceuticalsand natural products to construct a medium-sized polyfused heterocycledemonstrates the synthetic utility of the protocol.
引用
收藏
页码：5406 / 5410
页数：5
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