Screen for New Antimicrobial Natural Products from the NCI Program for Natural Product Discovery Prefractionated Extract Library

被引：14

作者：

Martinez-Fructuoso, Lucero ^{[1
]}

Arends, S. J. Ryan ^{[2
]}

Freire, Vitor F. ^{[1
]}

Evans, Jason R. ^{[1
]}

DeVries, Sean ^{[2
]}

Peyser, Brian D. ^{[1
]}

Akee, Rhone K. ^{[3
]}

Thornburg, Christopher C. ^{[3
]}

Kumar, Rohitesh ^{[3
]}

Ensel, Susan ^{[3
,4
]}

Morgan, Gina M. ^{[2
]}

McConachie, Grant D. ^{[3
]}

Veeder, Nathan ^{[2
]}

Duncan, Leonard R. ^{[2
]}

Grkovic, Tanja ^{[1
,5
]}

O'Keefe, Barry R. ^{[1
,5
]}

机构：

[1] NCI, Nat Prod Branch, Dev Therapeut Program, Div Canc Treatment & Diag, Frederick, MD 21702 USA

[2] JMI Labs, North Liberty, IA 52317 USA

[3] Leidos Biomed Res Inc, Frederick Natl Lab Canc Res, Nat Prod Support Grp, Frederick, MD 21702 USA

[4] Hood Coll, Dept Chem & Phys, Frederick, MD 21701 USA

[5] NCI, Mol Targets Program, Ctr Canc Res, Frederick, MD 21702 USA

来源：

ACS INFECTIOUS DISEASES | 2023年 / 9卷 / 06期

基金：

美国国家卫生研究院;

关键词：

microbial pathogens; antibiotic; antimicrobial; antifungal; NPNPD prefractionated library; high-throughput screening; natural products; IMIDAZOLE ALKALOIDS; ANTIBIOTIC-RESISTANCE; SPONGE; MARINE; PETROSAMINE; CONSEQUENCES; NAAMIDINE;

D O I：

10.1021/acsinfecdis.3c00067

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The continuing emergence of antibiotic-resistant microbes highlights the need for the identification of new chemotypes with antimicrobial activity. One of the most prolific sources of antimicrobial molecules has been the systematic screening of natural product samples. The National Institute of Allergy and Infectious Diseases and the National Cancer Institute here report a large screen of 326,656 partially purified natural product fractions against a panel of four microbial pathogens, resulting in the identification of >3000 fractions with antifungal and/or antibacterial activity. A small sample of these active fractions was further purified and the chemical structures responsible for the antimicrobial activity were elucidated. The proof-of-concept study identified many different chemotypes, several of which have not previously been reported to have antimicrobial activity. The results show that there remain many unidentified antibiotic compounds from nature.

引用

页码：1245 / 1256

页数：12

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